Evidence map›Paper›PMID 33732964›Full record

ReviewBioactive materials2021

Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal.

Meihan Tao, Tianrang Ao, Xiaoyan Mao, Xinzhu Yan, Rabia Javed, Weijian Hou, Yang Wang, Cong Sun, Shuang Lin, Tianhao Yu and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 114 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Sterilization Effects on Liposomes with Varying Lipid Chains.Nanomaterials (Basel, Switzerland) · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Meihan TaoDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Tianrang AoChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Xiaoyan MaoDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Xinzhu YanDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Rabia JavedDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Weijian HouDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Yang WangDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Cong SunDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Shuang LinDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Tianhao YuThe VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China.
Qiang AoDepartment of Tissue Engineering, China Medical University, Shenyang, China.
China Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sterilization is the process of killing all microorganisms, while disinfection is the process of killing or removing all kinds of pathogenic microorganisms except bacterial spores. Biomaterials involved in cell experiments, animal experiments, and clinical applications need to be in the aseptic state, but their physical and chemical properties as well as biological activities can be affected by sterilization or disinfection. Decellularized matrix (dECM) is the low immunogenicity material obtained by removing cells from tissues, which retains many inherent components in tissues such as proteins and proteoglycans. But there are few studies concerning the effects of sterilization or disinfection on dECM, and the systematic introduction of sterilization or disinfection for dECM is even less. Therefore, this review systematically introduces and analyzes the mechanism, advantages, disadvantages, and applications of various sterilization and disinfection methods, discusses the factors influencing the selection of sterilization and disinfection methods, summarizes the sterilization and disinfection methods for various common dECM, and finally proposes a graphical route for selecting an appropriate sterilization or disinfection method for dECM and a technical route for validating the selected method, so as to provide the reference and basis for choosing more appropriate sterilization or disinfection methods of various dECM.

Indexed as

AlcoholAntibioticDecellularized matrixDisinfectionEthylene oxideHydrogen peroxideIrradiationPeracetic acidSterilizationSupercritical carbon dioxide

Identifiers

PMID33732964
PMCPMC7930362
OpenAlexW3134529887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.