Evidence map›Paper›PMID 33732653›Full record

ArticleFrontiers in oncology2021

Case Report: Combined CDK4/6 and MEK Inhibition in Refractory CDKN2A and NRAS Mutant Melanoma.

Andrea Forschner, Tobias Sinnberg, Gabi Mroz, Christopher Schroeder, Christian Philipp Reinert, Sergios Gatidis, Michael Bitzer, Thomas Eigentler, Claus Garbe, Heike Niessner and 7 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Case Report: FGFR2 inhibitor resistance viaFrontiers in oncology · 2025
    Article
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  3. Review
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  5. High-multiplex tissue imaging in routine pathology-are we there yet?Virchows Archiv : an international journal of pathology · 2023
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Andrea ForschnerDepartment of Dermatology, University Hospital Tübingen, Tübingen, Germany.
Tobias SinnbergDepartment of Dermatology, University Hospital Tübingen, Tübingen, Germany.
Gabi MrozDepartment of Dermatology, University Hospital Tübingen, Tübingen, Germany.
Christopher SchroederInstitute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Tübingen, Germany.
Christian Philipp ReinertDepartment of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.
Sergios GatidisDepartment of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.
Michael BitzerDepartment of Internal Medicine, University Hospital Tübingen, Tübingen, Germany.
Thomas EigentlerDepartment of Dermatology, University Hospital Tübingen, Tübingen, Germany.
Claus GarbeDepartment of Dermatology, University Hospital Tübingen, Tübingen, Germany.
Heike NiessnerDepartment of Dermatology, University Hospital Tübingen, Tübingen, Germany.
Martin RöckenDepartment of Dermatology, University Hospital Tübingen, Tübingen, Germany.
Cristiana RoggiaInstitute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Tübingen, Germany.
Sorin Armeanu-EbingerInstitute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Tübingen, Germany.
Olaf RiessiFIT Cluster of Excellence (EXC 2180), University of Tübingen, Tübingen, Germany.
Sven MatternInstitute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.
Dominik NannInstitute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.
Irina BonzheimInstitute of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.
University Children's Hospital Tübingen · DEUniversity of Tübingen · DEDeutsche Forschungsgemeinschaft · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are only limited treatment options for metastatic

Indexed as

binimetinibCDKN2AmelanomaNRASribociclib

Identifiers

PMID33732653
PMCPMC7959243
OpenAlexW3135344087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.