ReviewNanotheranostics2021
The unfavorable role of titanium particles released from dental implants.
Review in Nanotheranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 72 citations in OpenAlex.
- Titanium Degradation Products from Dental Implants: Mechanisms of Release, Biodistribution, and Analytical Detection in Biological Matrices.International journal of molecular sciences · 2026Review
- Detection of submicron titanium debris associated with peri-implantitis.Discover nano · 2026Review
- Beyond the germ: Rethinking implant-related infections as a host-microbiota-biomaterial ecosystem.Biofilm · 2026Review
- A Redox Amplification Interface Linking Mitochondrial Dysfunction, Immune-Derived Oxidants, and Biomaterial Electrochemistry in Chronic Inflammation.International journal of molecular sciences · 2026Review
- Effect of Rare-Earth Element Microdoping on Ti-6Al-7Nb Alloys for Biomedical Applications: Materials Characterization and In Vivo Biocompatibility Tests.Materials (Basel, Switzerland) · 2026Article
- Targeted repair of oral mucosal injury: emerging applications of biomaterials-based drug delivery systems.Journal of nanobiotechnology · 2026Review
- Immunological and tissue reactions to titanium particles generated by the mechanical decontamination of dental implants: In vitro and in vivo study.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Comparative study of serum titanium levels in patients before and after dental implant placement.Bioinformation · 2026Article
- Long term follow-up of immediately temporized zirconia and titanium one-piece dental implants-a prospective cohort study.International journal of implant dentistry · 2025Article
- Comparative analysis of gingival crevicular fluid and peri-implant crevicular fluid by mid-infrared spectroscopy: a split mouth study.Clinical oral investigations · 2025Article
- Current State of Knowledge Regarding the Treatment of Cranial Bone Defects: An Overview.Materials (Basel, Switzerland) · 2025Review
- Impact of Titanium Plate Fixation on Diacylglycerol and Growth Factor Levels in the Periosteum of the Mandible and Maxilla in Patients with Dentofacial Deformities After Jaw Osteotomies.International journal of molecular sciences · 2025Article
- Navigating oxidative stress in oral bone regeneration: mechanisms and reactive oxygen species-regulating biomaterial strategies.Regenerative biomaterials · 2025Review
- The systemic and local interactions related to titanium implant corrosion and hypersensitivity reactions: a narrative review of the literature.International journal of implant dentistry · 2024Review
- Protein profile at newly restored implants compared to contralateral teeth over 12-months: a pilot study.Clinical oral investigations · 2024Observational
- Titanium nanoparticles released from orthopedic implants induce muscle fibrosis via activation of SNAI2.Journal of nanobiotechnology · 2024Article
- Blood metal concentrations and cardiac structure and function in total joint arthroplasty patients.World journal of orthopedics · 2024Article
- Maintenance of acetabular correction following PAO: a multicenter study comparing stainless-steel and titanium screws.Journal of hip preservation surgery · 2024Article
- On the Use of Nanoparticles in Dental Implants.Materials (Basel, Switzerland) · 2024Review
- Innovative Bioactive Ca-SZ Coating on Titanium Dental Implants: A Multidimensional Structural and Elemental Analysis.Journal of functional biomaterials · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium is considered to be a metal material with the best biological safety. Studies have proved that the titanium implanted in the bone continuously releases titanium particles (Ti particles), significantly increasing the total titanium content in human body. Generally, Ti particles are released slowly without causing a systemic immune response. However, the continuous increased local concentration may result in damage to the intraepithelial homeostasis, aggravation of inflammatory reaction in the surrounding tissues, bone resorption and implant detachment. They also migrate with blood flow and aggregate in the distal organ. The release of Ti particles is affected by the score of the implant surface structure, microenvironment wear and corrosion, medical operation wear, and so on, but the specific mechanism is not clear. Thus, it difficult to prevent the release completely. This paper reviews the causes of the Ti particles formation, the damage to the surrounding tissue, and its mechanism, in particular, methods for reducing the release and toxicity of the Ti particles.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.