Evidence map›Paper›PMID 33732602›Full record

ArticleNanotheranostics2021

Pulmonary fate and consequences of transferrin-functionalized gold nanoparticles.

Nagarjun Venkata Konduru, Karen Velasco-Alzate, Sitaramaraju Adduri, Kyryl Zagorovsky, Daysi Diaz-Diestra, Faisalina Fisol, Marcelo Sanches, Harrison Ndetan, Joseph David Brain, Ramon Morales Molina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotheranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The Opposite Roles of Benzo[Environment & health (Washington, D.C.) · 2026
    Article
  3. Pharmacokinetics and tumor delivery of nanoparticles.Journal of drug delivery science and technology · 2023
    Article
  4. Article
  5. Pulmonary Delivery of Nonviral Nucleic Acid-Based Vaccines With Spotlight on Gold Nanoparticles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nagarjun Venkata KonduruDepartment of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, 11937 U.S. Hwy 271, Tyler, TX 75708, USA.
Karen Velasco-AlzateDepartment of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, 11937 U.S. Hwy 271, Tyler, TX 75708, USA.
Sitaramaraju AdduriDepartment of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, 11937 U.S. Hwy 271, Tyler, TX 75708, USA.
Kyryl ZagorovskyLuna Nanotech Inc., 439 University Avenue, 5th Floor, Toronto, ON, Canada M5G 1Y8.
Daysi Diaz-DiestraCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Faisalina FisolCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Marcelo SanchesCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Harrison NdetanDepartment of Biostatistics, University of Texas Health Science Center at Tyler, 11937 U.S. Hwy 271, Tyler, TX 75708, USA.
Joseph David BrainCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Ramon Morales MolinaCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Harvard University · USThe University of Texas Health Science Center at Tyler · USApplied Nanotech (United States) · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
Lipoprotein Corona Fingerprints: Implications for Pulmonary Clearance and Toxicity of Engineered NanoparticlesR00ES025813 · NIEHS · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI KONDURU VENKATA, NAGARJUN · 2019 to 2021
$747k
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R00 ES025813NIGMS NIH HHS R25 GM061151
6 · The paper itself

Abstract

Surface functionalization of nanoparticles (NPs) may alter their biological interactions such as uptake by alveolar macrophages (AMs). Pulmonary delivery of gold NPs (Au NPs) has theranostic potential due to their optoelectronic properties, minimal alveoli to blood translocation, and possibility of specific cell targeting. Here, we examined whether coating Au NPs with transferrin alters their protein corona, uptake by macrophages, and pulmonary translocation.

Indexed as

AdultAnimalsBronchoalveolar Lavage FluidDrug Delivery SystemsGoldHumansLungMacrophages, AlveolarMaleMetal NanoparticlesPharmacokineticsProtein CoronaRatsRats, WistarTransferrinGoldProtein CoronaTransferrinalveolar macrophagelung clearanceorgan retentionprimary human monocyte-derived macrophagesprotein corona

Identifiers

PMID33732602
PMCPMC7961126
OpenAlexW3137306984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.