ArticleRegenerative biomaterials2021
The effect of LyPRP/collagen composite hydrogel on osteogenic differentiation of rBMSCs.
Article in Regenerative biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- PRP-related biomaterials enhance bone and nerve repair.Materials today. Bio · 2026Review
- Comprehensive Review on Application Progress of Marine Collagen Cross-Linking Modification in Bone Repairs.Marine drugs · 2025Review
- Porous PLLA microspheres dispersed in HA/collagen hydrogel as injectable facial fillers to enhance aesthetic effects.Regenerative biomaterials · 2025Article
- Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration.Bioactive materials · 2022Article
- Poly (Butylene Succinate)/Silicon Nitride Nanocomposite with Optimized Physicochemical Properties, Biocompatibility, Degradability, and Osteogenesis for Cranial Bone Repair.Journal of functional biomaterials · 2022Article
- Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022Review
- Is polydopamine beneficial for cells on the modified surface?Regenerative biomaterials · 2022Article
- Effects of compound stimulation of fluid shear stress plus ultrasound on stem cell proliferation and osteogenesis.Regenerative biomaterials · 2021Article
- Evaluation of the immunomodulatory effects of cobalt, copper and magnesium ions in a pro inflammatory environment.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although platelet-rich plasma (PRP) plays a significant role in the orthopedic clinical application, it still faces two major problems, namely, uncontrollable factors release, frequent preparation and extraction processes as well as the inconvenient form of usage. To overcome these shortcomings, freeze-dried PRP (LyPRP) was encapsulated into bioactive Col I hydrogel to induce osteogenic differentiation of rabbit bone marrow mesenchymal stem cells (rBMSCs). And PRP/Col І composite hydrogel was prepared as a control. Compared with Col І hydrogel, the introduction of platelets significantly improved the mechanical properties of hydrogels. Meanwhile, platelets were evenly distributed in the composite hydrogels network. The sustainable release of related factors in the composite hydrogels could last for more than 14 days to maintain its long-term biological activity. Further cell experiments confirmed that PRP and LyPRP could effectively alleviate the contraction of collagen hydrogel
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.