ArticleRegenerative biomaterials2021
Development of FGF-2-loaded electrospun waterborne polyurethane fibrous membranes for bone regeneration.
Article in Regenerative biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- The application of growth factors in bone tissue engineering delivery systems and collaborative innovation strategies.Annals of medicine · 2026Review
- Multifunctional Shape-Memory Polyurethane/MnOMaterials (Basel, Switzerland) · 2026Article
- Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review).International journal of molecular medicine · 2026Review
- Eco-Friendly Fabrication of Secretome-Loaded, Glutathione-Extended Waterborne Polyurethane Nanofibers.International journal of molecular sciences · 2025Article
- Article
- Polydopamine-Coated Copper-Doped Mesoporous Silica/Gelatin-Waterborne Polyurethane Composite: A Multifunctional GBR Membrane Bone Defect Repair.Journal of functional biomaterials · 2025Article
- Fabrication of Waterborne Silicone-Modified Polyurethane Nanofibers for Nonfluorine Elastic Waterproof and Breathable Membranes.Polymers · 2024Article
- The use of hydrogel microspheres as cell and drug delivery carriers for bone, cartilage, and soft tissue regeneration.Biomaterials translational · 2024Review
- Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway.Regenerative biomaterials · 2024Article
- Application of metal-organic frameworks-based functional composite scaffolds in tissue engineering.Regenerative biomaterials · 2024Review
- Electrospun Polysaccharides for Periodontal Tissue Engineering: A Review of Recent Advances and Future Perspectives.Annals of biomedical engineering · 2022Review
- Effects of compound stimulation of fluid shear stress plus ultrasound on stem cell proliferation and osteogenesis.Regenerative biomaterials · 2021Article
- Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guided bone regeneration (GBR) membrane has been used to improve functional outcomes for periodontal regeneration. However, few studies have focused on the biomimetic membrane mimicking the vascularization of the periodontal membrane. This study aimed to fabricate waterborne polyurethane (WPU) fibrous membranes loaded fibroblast growth factor-2 (FGF-2) via emulsion electrospinning, which can promote regeneration of periodontal tissue via the vascularization of the biomimetic GBR membrane. A biodegradable WPU was synthesized by using lysine and dimethylpropionic acid as chain extenders according to the rule of green chemical synthesis technology. The WPU fibers with FGF-2 was fabricated via emulsion electrospinning. The results confirmed that controlled properties of the fibrous membrane had been achieved with controlled degradation, suitable mechanical properties and sustained release of the factor. The immunohistochemical expression of angiogenic-related factors was positive, meaning that FGF-2 loaded in fibers can significantly promote cell vascularization. The fiber scaffold loaded FGF-2 has the potential to be used as a functional GBR membrane to promote the formation of extraosseous blood vessels during periodontal repairing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.