Evidence map›Paper›PMID 33732448›Full record

ArticleRSC advances2020

Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds.

Willy Carrasquel-Ursulaez, Ryan D Reeves, Mahzad Dehghany, Corey Jones, Jennifer M Schomaker, Baron Chanda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Antimicrobial and Adjuvant Potencies of Di-Antibiotics (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Willy Carrasquel-UrsulaezDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA.
Ryan D ReevesDepartment of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
Mahzad DehghanyDepartment of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.ORCID 0000-0002-5596-4814
Corey JonesDepartment of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
Jennifer M SchomakerDepartment of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.ORCID 0000-0003-1329-950X
Baron ChandaDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA.

Funding

Biophysical mechanisms of gating and modulation in voltage-gated ion channel superfamilyR35NS116850 · NINDS · WASHINGTON UNIVERSITY · PI Baron Chanda · 2020 to 2026
$6.9M
Synthetic design of an all-optical electrophysiology systemR21GM131662 · NIGMS · WASHINGTON UNIVERSITY · PI CHANDA, BARON, SCHOMAKER, JENNIFER MARIE · 2019 to 2020
$395k
NIGMS NIH HHS R21 GM131662NINDS NIH HHS R35 NS116850
6 · The paper itself

Abstract

The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionophores.

Identifiers

PMID33732448
PMCPMC7963367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.