Evidence map›Paper›PMID 33732434›Full record

ArticleF1000Research2021

IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain.

Mauricio Fernandes, Magdalena Schelotto, Philipp Maximilian Doldi, Giovanna Milani, Abul Andrés Ariza Manzano, Doriam Perera Valdivia, Alexandra Marie Winter Matos, Yasmin Hamdy Abdelrahim, Shaza Ahmed Hamad Bek, Benito K Benitez and 16 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in F1000Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 19 institutions in 12 countries.

Mauricio Fernandes *Dresden International University, Dresden, Germany.
Magdalena Schelotto *Universidad de la República (UdelaR)., Montevideo, Uruguay.
Philipp Maximilian Doldi *Dresden International University, Dresden, Germany.
Giovanna MilaniABC School of Medicine, Sao Paulo, Brazil.ORCID 0000-0003-2664-7593
Abul Andrés Ariza ManzanoColegio Mayor de Nuestra Señora del Rosario, Bogota, Colombia.
Doriam Perera ValdiviaNational Autonomous University of Nicaragua, Manangua, Nicaragua.
Alexandra Marie Winter MatosUniversidad Iberoamericana (UNIBE), Santo Domingo, Dominican Republic.
Yasmin Hamdy AbdelrahimDepartment of Old Age Psychiatry, Doha, Qatar.
Shaza Ahmed Hamad BekNational Center for Cancer Care and Research, Doha, Qatar.
Benito K BenitezDepartment of Oral and Craniomaxillofacial Surgery, Basel, Switzerland.
Vanessa Luiza Romanelli TavaresHuman Genome and Stem Cell Research Center, Sao Paulo, Brazil.ORCID 0000-0002-8845-5952
Abdulrahim M BasendwahOncology Division, Internal Medicine Department, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.ORCID 0000-0002-8849-8629
Luis Henrique Albuquerque SousaNeurosurgery Department, University of Sao Paulo (USP), Sao Paulo, Brazil.
Naiara Faria XavierOphthalmology Department, University of Sao Paulo, Sao Paulo, Brazil.
Tania Zertuche MaldonadoTecnológico de Monterrey, Escuela de Medicina Y Ciências de la Salud, Monterrey, Mexico.
Sarah Toyomi de OliveiraUniversity of Sao Paulo (USP), Sao Paulo, Brazil.
Melisa ChakerDepartment of Pediatric Cardiology, Hospital Nacional de Pediatría Juan Pedro Garrahan, Buenos Aires, Argentina.
Michelle Menon MiyakeDepartment of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, USA.ORCID 0000-0001-8588-4834
Elif Uygur KucukseymenNeuromodulation Center and Center for Clinical Research Learning. Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Boston, USA.
Kinza WaqarNational University of Sciences and Technology, Islamabad, Pakistan.
Ola M J AlkhozondarDepartment of Pharmacy Clinical Informatics, Hamad Medical Corporation, Doha, Qatar.
Ricardo Bernardo da SilvaDepartment of Vascular and Endovascular Surgery, Pontifical Catholic University of Paraná, Londrina, Brazil.
Guilhermo Droppelmann23- Academic Unit. Clinica MEDS., Santiago, Chile.
Antonio Vaz de MacedoPPCR Program, ECPE, Harvard T.H. Chan School of Public Health, Boston, USA.
Rui NakamuraPPCR Program, ECPE, Harvard T.H. Chan School of Public Health, Boston, USA.
Felipe FregniPPCR Program, ECPE, Harvard T.H. Chan School of Public Health, Boston, USA.
Harvard University · USUniversidade de São Paulo · BRClínica MEDS (Chile) · CLDresden International University · DEFaculdade de Medicina do ABC · BRGarrahan Hospital · ARHamad Medical Corporation · QAHospital Universitário da Universidade de São Paulo · BRKing Fahd Armed Forces Hospital · SALMU Klinikum · DEMassachusetts Eye and Ear Infirmary · USNational Autonomous University of Nicaragua · NINational Center for Cancer Care and Research · QANational University of Sciences and Technology · PKPontifícia Universidade Católica do Paraná · BRSpaulding Rehabilitation Hospital · USTecnológico de Monterrey · MXUniversidad de la República de Uruguay · UYUniversidad Iberoamericana · DO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chronic PainIntractable PainKetamineAnalgesics, OpioidClinical Trials, Phase II as TopicDouble-Blind MethodHumansQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeAnalgesics, OpioidEsketamineKetamineCancer painEsketamineOpioid refractoryPain measurement

Identifiers

PMID33732434
PMCPMC7885290
OpenAlexW3125524977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.