Evidence map›Paper›PMID 33732378›Full record

ReviewOncology letters2021

The HOTAIR lncRNA: A remarkable oncogenic promoter in human cancer metastasis.

Lili Chen, Xinle Qian, Zhongqi Wang, Xiqiu Zhou

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Rapid Exploratory Data Visualization for Cancer Genomics.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  8. LncRNA-Histone Modification Crosstalk: Orchestrating Cancer Pathobiology.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Non-Coding RNAs in Breast Cancer: Diagnostic and Therapeutic Implications.International journal of molecular sciences · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lili ChenDepartment of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China.
Xinle QianDepartment of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China.
Zhongqi WangDepartment of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China.
Xiqiu ZhouDepartment of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China.
Shanghai University of Traditional Chinese Medicine · CNLonghua Hospital Shanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNA (lncRNA) is a new type of non-coding RNA that has an important regulatory influence on several human diseases, including cancer metastasis. HOX antisense intergenic RNA (HOTAIR), a newly discovered lncRNA, has an important effect on tumour proliferation, migration and metastasis. HOTAIR regulates cell proliferation, changes gene expression, and promotes tumour cell invasion and migration. However, its molecular mechanism of action remains unknown. The present review summarizes the molecular mechanism and role of HOTAIR in tumour invasion and metastasis, discusses the association between HOTAIR and tumour metastasis through different pathways, such as the transforming growth factor β, Wnt/β-catenin, PI3K/AKT/MAPK and vascular endothelial growth factor pathways, emphasizes the function of HOTAIR in human malignant tumour metastasis and provides a foundation for its application in the diagnosis, prognosis and medical treatment of various tumours.

Indexed as

HOX antisense intergenic RNAPI3K/AKT/MAPK signal pathwayTGF-β signalling pathwaytumour metastasisVEGF signalling pathwayWnt/β-catenin signalling pathway

Identifiers

PMID33732378
PMCPMC7905531
OpenAlexW3131222605

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.