Evidence map›Paper›PMID 33732335›Full record

ArticleExperimental and therapeutic medicine2021

COVID-19-associated meningoencephalitis: A care report and literature review.

Pu Lv, Fen Peng, Yeqiong Zhang, Linwei Zhang, Na Li, Lili Sun, Yu Wang, Pihua Hou, Tiequn Huang, Xiaoping Wang

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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  15. COVID-19 and encephalitis.Encephalitis (Seoul, Korea) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Pu LvDepartment of Healthcare, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.
Fen PengDepartment of Cardiology, Renmin Hospital of Hubei Province, Wuhan, Hubei 430060, P.R. China.
Yeqiong ZhangDepartment of Neurology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.
Linwei ZhangDepartment of Neurology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.
Na LiDepartment of Healthcare, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.
Lili SunDepartment of Neurology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.
Yu WangDepartment of Neurology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.
Pihua HouDepartment of Healthcare, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.
Tiequn HuangDepartment of Healthcare, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.
Xiaoping WangDepartment of Healthcare, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, P.R. China.
China-Japan Friendship Hospital · CNRenmin Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may target the central nervous system and several neurological symptoms have been reported in patients with coronavirus disease 2019 (COVID-19). In the present study, a case of a SARS-CoV-2 complicated with meningoencephalitis was reported. Cerebrospinal fluid (CSF) analyses indicated hyperproteinorrachia but the specimen was negative for SARS-CoV-2 RNA. Furthermore, 10 published articles reporting on patients with COVID-19-associated meningitis/encephalitis were reviewed. Patients diagnosed with COVID-19-associated meningitis/encephalitis had diverse clinical neurological manifestations, including consciousness disturbance, epileptic attacks, psychotic syndrome and meningeal irritation signs. CSF tests revealed elevated protein, lymphocytes and cytokines. SARS-CoV-2 may be detected in the CSF of certain cases. Neuroimaging findings included hyperintense signal changes in the white matter and enhancement of meninges on brain MRI. Certain patients responded well to corticosteroid therapy and had a favorable prognosis, while elderly patients tended to have poor outcomes due to multiple organ dysfunction.

Indexed as

central nervous systemCOVID-19encephalitismeningitis

Identifiers

PMID33732335
PMCPMC7903472
OpenAlexW3131529879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.