ArticleFrontiers in immunology2021
Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice.
Open access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review.Particle and fibre toxicology · 2024Pooled it
- Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review.Particle and fibre toxicology · 2022Pooled it
- Occupational and Hobby Exposures Associated With Myositis Phenotypes in a National Myositis Patient Registry.Arthritis care & research · 2025Article
- Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing.Particle and fibre toxicology · 2024Article
- Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases.Journal of translational autoimmunity · 2024Review
- Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2024Review
- Article
- Dietary docosahexaenoic acid supplementation inhibits acute pulmonary transcriptional and autoantibody responses to a single crystalline silica exposure in lupus-prone mice.Frontiers in immunology · 2024Article
- No causal association between pneumoconiosis and three inflammatory immune diseases: a Mendelian randomization study.Frontiers in public health · 2024Article
- Pneumoconiosis combined with connective tissue disease in China: a cross-sectional study.BMJ open · 2023Article
- Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure.Archives of toxicology · 2023Article
- Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis.Frontiers in immunology · 2023Review
- Pulmonary Toxicity of Silica Linked to Its Micro- or Nanometric Particle Size and Crystal Structure: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- The significance of serum S100 calcium-binding protein A4 in silicosis.BMC pulmonary medicine · 2022Article
- Autoreactive B cells recruited to lungs by silica exposure contribute to local autoantibody production in autoimmune-prone BXSB and B cell receptor transgenic mice.Frontiers in immunology · 2022Article
- C-X-C-Chemokine-Receptor-Type-4 Inhibitor AMD3100 Attenuates Pulmonary Inflammation and Fibrosis in Silicotic Mice.Journal of inflammation research · 2022Article
- Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development.Frontiers in toxicology · 2022Review
- Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation.Frontiers in immunology · 2021Article
- Modeling environmental inhalant exposure in rheumatoid arthritis.Inhalation toxicologyReview
- Amphibole asbestos as an environmental trigger for systemic autoimmune diseases.Autoimmunity reviewsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Preeti S ChauhanDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.
James G WagnerInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Abby D BenninghoffDepartment of Animal, Dairy and Veterinary Sciences, School of Veterinary Medicine, Utah State University, Logan, UT, United States.
Ryan P LewandowskiDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States.
Olivia K FavorInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Kathryn A WierengaInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Kristen N GilleyDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.
Elizabeth A RossDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.
Jack R HarkemaInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
James J PestkaDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.
Michigan State University · USUtah State University · US
Funding
MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3MRole of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.R01ES027353 · NIEHS · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2017 to 2026
$4.8MIntegrative Training in the Pharmacological SciencesT32GM092715 · NIGMS · MICHIGAN STATE UNIVERSITY · PI NEUBIG, RICHARD R · 2011 to 2020
$1.5MOmega-3 Fatty Acid Suppression of Silica-induced Inflammasome Activation in a Novel Alveolar Macrophage ModelF31ES030593 · NIEHS · MICHIGAN STATE UNIVERSITY · PI WIERENGA, KATHRYN ALEXANDRIA · 2019 to 2021
$90kNIEHS NIH HHS F31 ES030593NIEHS NIH HHS R01 ES027353NIEHS NIH HHS T32 ES007255NIGMS NIH HHS T32 GM092715
Abstract
Occupational exposure to crystalline silica (cSiO
Indexed as
AutoimmunityAnimalsB-LymphocytesChemotaxis, LeukocyteCytokinesDisease Models, AnimalFemaleGene Expression RegulationGene Regulatory NetworksInflammation MediatorsLungLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred NZBPneumoniaCytokinesInflammation MediatorsSilicon Dioxideautoimmune diseaseB cellchemokinescrystalline silicalung pathologysystemic lupus erythematosusT celltype I interferon
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.