Evidence map›Paper›PMID 33732252›Full record

ArticleFrontiers in immunology2021

Clinical and Molecular Findings in Mendelian Susceptibility to Mycobacterial Diseases: Experience From India.

Prasad D Taur, Vijaya Gowri, Ambreen Abdulwahab Pandrowala, Vaishnavi V Iyengar, Akshaya Chougule, Zainab Golwala, Shraddha Chandak, Reepa Agarwal, Purva Keni, Neha Dighe and 33 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 17 institutions in 3 countries.

Prasad D TaurDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Vijaya GowriDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Ambreen Abdulwahab PandrowalaDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Vaishnavi V IyengarDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Akshaya ChouguleDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Zainab GolwalaDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Shraddha ChandakDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Reepa AgarwalDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Purva KeniDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Neha DigheDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Minnie BodhanwalaDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Shakuntala PrabhuDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Biju GeorgeDepartment of Clinical Hematology, Christian Medical College, Vellore, India.
N A FouziaDepartment of Clinical Hematology, Christian Medical College, Vellore, India.
Eunice Sindhuvi EdisonDepartment of Clinical Hematology, Christian Medical College, Vellore, India.
Arun Kumar ArunachalamDepartment of Clinical Hematology, Christian Medical College, Vellore, India.
Manisha Rajan MadkaikarIndian Council of Medical Research-National Institute of Immunohematology, Mumbai, India.
Aparna Dhondi DalviIndian Council of Medical Research-National Institute of Immunohematology, Mumbai, India.
Reetika Malik YadavIndian Council of Medical Research-National Institute of Immunohematology, Mumbai, India.
Umair Ahmed BargirIndian Council of Medical Research-National Institute of Immunohematology, Mumbai, India.
Priyanka Madhav KambliIndian Council of Medical Research-National Institute of Immunohematology, Mumbai, India.
Amit RawatDepartment of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Jhumki DasDepartment of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Vibhu JoshiDepartment of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Rakesh Kumar PilaniaDepartment of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ankur Kumar JindalDepartment of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Sunil BhatMazumdar Shaw Cancer Centre, Narayana Health City, Bengaluru, India.
Sagar BhattadASTER CMI Hospitals, Bengaluru, India.
Jeeson UnniASTER CMI Hospitals, Bengaluru, India.
Nita RadhakrishnanSuperspeciality Hospital, Noida, India.
Revathi RajApollo Hospitals, Chennai, India.
Ramya UppuluriApollo Hospitals, Chennai, India.
Shivani PatelApollo Hospitals, Chennai, India.
Harsha Prasada LashkariKasturba Medical College and Hospital, Mangalore, India.
Amita AggarwalDepartment of Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Manas KalraSir Ganga Ram Hospital, New Delhi, India.
Zarir UdwadiaHinduja Hospital, Mumbai, India.
Vibha Sanjay BafnaBharati Hospital, Pune, India.
Tarun KanadeRainbow Safalya Hospital, Nashik, India.
Anne PuelUniversity of Paris, Institute Imagine, INSERM, Paris, France.
Jacinta BustamanteUniversity of Paris, Institute Imagine, INSERM, Paris, France.
Jean Laurent CasanovaUniversity of Paris, Institute Imagine, INSERM, Paris, France.
Mukesh M DesaiDepartment of Immunology, B. J. Wadia Hospital for Children, Mumbai, India.
Bai Jerbai Wadia Hospital for Children · INPost Graduate Institute of Medical Education and Research · INChristian Medical College & Hospital · INIndian Council of Medical Research · INApollo Hospitals · INBharati Vidyapeeth Deemed University · INInserm · FRKasturba Medical College, Manipal · INNarayana Health · INNational Institute of Immunohaematology · INNethradhama Superspeciality Eye Hospital · INP. D. Hinduja Hospital and Medical Research Centre · INRainbow Children's Hospital · INRockefeller University · USSanjay Gandhi Post Graduate Institute of Medical Sciences · INSir Ganga Ram Hospital · INUniversité Paris Cité · FR

Funding

Genome-Wide Dissection of Mendelian Susceptibility to Mycobacterial DiseaseR37AI095983 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT · 2011 to 2020
$4.6M
NIAID NIH HHS R37 AI095983
6 · The paper itself

Abstract

Mendelian Susceptibility to Mycobacterial diseases (MSMD) are a group of innate immune defects with more than 17 genes and 32 clinical phenotypes identified. Defects in the IFN-γ mediated immunity lead to an increased susceptibility to intracellular pathogens like mycobacteria including attenuated

Indexed as

MutationAdolescentAdultBCG VaccineChildChild, PreschoolCoinfectionFemaleGenetic Predisposition to DiseaseHumansImmunity, InnateIndiaInfantInfant, NewbornMaleMycobacterium InfectionsBCG VaccineIL12RB1 protein, humanReceptors, Interleukin-12anti-tubercular treatmentBCG-osisIL-12/IL-23/ISG15/IFN-γ axisIL-12Rβ1 defectintracellular pathogensMycobacterium tuberculosis complex

Identifiers

PMID33732252
PMCPMC7959731
OpenAlexW3134365313

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.