Evidence map›Paper›PMID 33732242›Full record

ArticleFrontiers in immunology2021

Dietary Oxalate Loading Impacts Monocyte Metabolism and Inflammatory Signaling in Humans.

Parveen Kumar, Mikita Patel, Robert A Oster, Vidhush Yarlagadda, Adam Ambrosetti, Dean G Assimos, Tanecia Mitchell

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03877276 (Dietary Oxalate and Immune Cell Function), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03877276 naactive not recruitingnot on this map

Dietary Oxalate and Immune Cell Function

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2016 to 2029Enrolled82ConditionsKidney StoneArmsBreakfast, Spinach smoothie, Kale smoothie, Blended smoothie, V spinach smoothie
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. The effects of elevated phosphate on the kidney - damaging the gatekeeper.Pflugers Archiv : European journal of physiology · 2026
    Review
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  13. Novel Translational Approaches To Study Kidney Disease.Journal of visualized experiments : JoVE · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Parveen KumarDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, United States.
Mikita PatelDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, United States.
Robert A OsterDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Vidhush YarlagaddaDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, United States.
Adam AmbrosettiDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, United States.
Dean G AssimosDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, United States.
Tanecia MitchellDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · US

Funding

National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MEHTA, RAVINDRA L. · 2008 to 2022
$18.3M
Monocyte Mitochondrial Dysfunction and Kidney Stone DiseaseK01DK106284 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MITCHELL, TANECIA R · 2016 to 2021
$912k
Dietary Oxalate and Innate Immunity in Kidney Stone DiseaseR03DK123542 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MITCHELL, TANECIA R · 2020 to 2021
$216k
NCATS NIH HHS UL1 TR003096NIDDK NIH HHS K01 DK106284NIDDK NIH HHS P30 DK079337NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R03 DK123542
6 · The paper itself

Abstract

Diet has been associated with several metabolic diseases and may impact immunity. Increased consumption of meals with high oxalate content may stimulate urinary calcium oxalate (CaOx) crystals, which are precursors to CaOx kidney stones. We previously reported that CaOx stone formers have decreased monocyte cellular bioenergetics compared to healthy participants and oxalate reduces monocyte metabolism and redox status Clinical Trial Registration: ClinicalTrials.gov, identifier NCT03877276.

Indexed as

Dietary SupplementsAdultBiomarkersElectron Transport Chain Complex ProteinsEnergy MetabolismFemaleHumansInflammationLeukocyte CountMaleMitochondriaMonocytesOxalatesSignal TransductionUrinalysisBiomarkersElectron Transport Chain Complex ProteinsOxalatesinflammationkidney stonesmetabolismmitochondriamonocytesoxalate

Identifiers

PMID33732242
PMCPMC7959803
OpenAlexW3133296940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.