Evidence map›Paper›PMID 33732165›Full record

ArticleFrontiers in physiology2021

Is Upregulation of Sarcolipin Beneficial or Detrimental to Muscle Function?

Naresh C Bal, Subash C Gupta, Meghna Pant, Danesh H Sopariwala, Geoffrey Gonzalez-Escobedo, Joanne Turner, John S Gunn, Christopher R Pierson, Scott Q Harper, Jill A Rafael-Fortney and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. SERCA blockade as a treatment strategy for obesity.European journal of applied physiology · 2025
    Review
  4. Hypertrophic cardiomyopathy: insights into pathophysiology and novel therapeutic strategies from clinical studies.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Review
  5. Article
  6. Article
  7. Altered contractility, CaAmerican journal of physiology. Heart and circulatory physiology · 2023
    Article
  8. Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. International journal of molecular sciences · 2022
    Article
  13. Altered skeletal muscle sarco-endoplasmic reticulum CaAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  14. Article
  15. Article
  16. CaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Naresh C BalSchool of Biotechnology, KIIT University, Bhubaneswar, India.
Subash C GuptaDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States.
Meghna PantDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States.
Danesh H SopariwalaDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States.
Geoffrey Gonzalez-EscobedoDepartments of Microbiology and Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
Joanne TurnerDepartments of Microbiology and Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
John S GunnDepartments of Microbiology and Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
Christopher R PiersonDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, United States.
Scott Q HarperDepartment of Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, United States.
Jill A Rafael-FortneyDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States.
Muthu PeriasamyDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States.
The Ohio State University · USNationwide Children's Hospital · USKIIT University · IN

Funding

RECRUITMENT OF SKELETAL MUSCLE BASED ON NON-SHIVERING THERMOGENESIS IN HEALTH AND DISEASER01DK098240 · NIDDK · UNIVERSITY OF CENTRAL FLORIDA · PI PERIASAMY, MUTHU · 2013 to 2017
$1.9M
Mechanisms regulating SR Ca2+ ATPase in the AtriaR01HL088555 · NHLBI · OHIO STATE UNIVERSITY · PI PERIASAMY, MUTHU · 2008 to 2012
$1.9M
NHLBI NIH HHS R01 HL088555NIDDK NIH HHS R01 DK098240
6 · The paper itself

Abstract

Sarcolipin (SLN) is a regulator of sarco/endo plasmic reticulum Ca

Indexed as

Ca2+-handling proteinsmuscle diseasesarco/endo plasmic reticulum Ca2+ ATPasesarcolipinskeletal muscle

Identifiers

PMID33732165
PMCPMC7956958
OpenAlexW3135359201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.