Evidence map›Paper›PMID 33732155›Full record

ArticleFrontiers in pharmacology2021

Common Endothelial Nitric Oxide Synthase Single Nucleotide Polymorphisms are not Related With the Risk for Restless Legs Syndrome.

Félix Javier Jiménez-Jiménez, Blanca G Agúndez, Javier Gómez-Tabales, Hortensia Alonso-Navarro, Laura Turpín-Fenoll, Jorge Millán-Pascual, Mónica Díez-Fairén, Ignacio Álvarez, Pau Pastor, Marisol Calleja and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. International journal of molecular sciences · 2025
    Article
  2. International journal of molecular sciences · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Félix Javier Jiménez-JiménezSection of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Spain.
Blanca G AgúndezUNEx, ARADyAL, University Institute of Molecular Pathology Biomarkers, Cáceres, Spain.
Javier Gómez-TabalesUNEx, ARADyAL, University Institute of Molecular Pathology Biomarkers, Cáceres, Spain.
Hortensia Alonso-NavarroSection of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Spain.
Laura Turpín-FenollSection of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Spain.
Jorge Millán-PascualSection of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Spain.
Mónica Díez-FairénFundació per la Recerca Biomèdica i Social Mútua de Terrassa, Barcelona, Spain.
Ignacio ÁlvarezFundació per la Recerca Biomèdica i Social Mútua de Terrassa, Barcelona, Spain.
Pau PastorFundació per la Recerca Biomèdica i Social Mútua de Terrassa, Barcelona, Spain.
Marisol CallejaSection of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Spain.
Rafael García-RuizSection of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Spain.
Santiago Navarro-MuñozSection of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Spain.
Marta Recio-BermejoSection of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Spain.
José Francisco Plaza-NietoSection of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Spain.
Esteban García-AlbeaDepartment of Medicine-Neurology, Universidad de Alcalá, Alcalá de Henares, Spain.
Elena García-MartínUNEx, ARADyAL, University Institute of Molecular Pathology Biomarkers, Cáceres, Spain.
José A G AgúndezUNEx, ARADyAL, University Institute of Molecular Pathology Biomarkers, Cáceres, Spain.
Hospital Universitario del Sureste · ESMútua Terrassa · ESUniversidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because nitric oxide and endothelial dysfunction could play a role in the pathogenesis of idiopathic restless legs syndrome (RLS), as was suggested by some preliminary data, we investigated the possible association between the rs2070744 variants in the

Indexed as

genetic polymorphismsgeneticsnitric oxidenitric oxide synthase genesrestless legs syndromerisk factors

Identifiers

PMID33732155
PMCPMC7959806
OpenAlexW3133712954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.