Evidence map›Paper›PMID 33731828›Full record

ArticleMucosal immunology2021

CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation.

Pedram Shafiei-Jahani, Doumet Georges Helou, Benjamin P Hurrell, Lauriane Galle-Treger, Emily Howard, Christine Quach, Jacob D Painter, Marshall Fung, Richard Lo, Hooman Allayee and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Enhancing autophagy in CD11cCell reports · 2023
    Article
  7. Article
  8. Article
  9. MelLec Exacerbates the Pathogenesis ofFrontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Pedram Shafiei-JahaniDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Doumet Georges HelouDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Benjamin P HurrellDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lauriane Galle-TregerDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Emily HowardDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Christine QuachDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jacob D PainterDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Marshall FungDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Richard LoDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hooman AllayeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Omid AkbariDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. akbari@usc.edu.ORCID http://orcid.org/0000-0002-4359-9725
University of Southern California · US

Funding

INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMAR01ES021801 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, ALLAYEE, HOOMAN · 2012 to 2016
$3.9M
Study the link of autophagy dysfunction to allergic and neutrophilic asthma onsetR01HL151493 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2020 to 2024
$3.6M
Role of Glycine Metabolism in Cardiovascular DiseaseR01HL133169 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN · 2017 to 2020
$3.3M
Maternal effect on offspring immunity against hepatitis B virusR01AI145813 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, OU, J.-H. JAMES · 2019 to 2023
$3.2M
Genetic and Environmental Determinants of Asthma EndophenotypesR01ES025786 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, ALLAYEE, HOOMAN · 2015 to 2019
$2.8M
Induction of cells and pathways that promote respiratory tolerance in allergic asthmaR01HL144790 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2019 to 2022
$2.6M
Biological Mechanisms through which TMAO Promotes AtherosclerosisR01HL148110 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN, SHIH, DIANA MOUHAN · 2020 to 2023
$2.5M
Role of Microbiome Sodium Butyrate in regulation of ILC2 dependent airway hyperreactivityR21AI132084 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2017 to 2018
$454k
NHLBI NIH HHS R01 HL133169NHLBI NIH HHS R01 HL144790NHLBI NIH HHS R01 HL148110NHLBI NIH HHS R01 HL151493NIAID NIH HHS R01 AI145813NIAID NIH HHS R21 AI132084NIEHS NIH HHS R01 ES021801NIEHS NIH HHS R01 ES025786
6 · The paper itself

Abstract

Allergic asthma is a chronic inflammatory disorder associated with airway hyperreactivity (AHR) whose global prevalence is increasing at an alarming rate. Group 2 innate lymphoid cells (ILC2s) and T helper 2 (T

Indexed as

Adaptive ImmunityAlemtuzumabAllergensAnimalsAnti-Inflammatory AgentsAntineoplastic Agents, ImmunologicalAsthmaCD52 AntigenDisease Models, AnimalDisease SusceptibilityDNA-Binding ProteinsHumansImmunity, InnateLymphocyte SubsetsMiceMice, KnockoutAlemtuzumabAllergensAnti-Inflammatory AgentsAntineoplastic Agents, ImmunologicalCD52 AntigenDNA-Binding ProteinsRag2 protein, mouse

Identifiers

PMID33731828
PMCPMC8225558
OpenAlexW3137215143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.