Evidence map›Paper›PMID 33731821›Full record

Trial reportScientific reports2021

Real time and delayed effects of subcortical low intensity focused ultrasound.

Joshua A Cain, Shakthi Visagan, Micah A Johnson, Julia Crone, Robin Blades, Norman M Spivak, David W Shattuck, Martin M Monti

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07518927 (Mapping Low-Intensity Focused Ultrasound), which is not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07518927 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Mapping Low-Intensity Focused Ultrasound (LIFU)-Evoked Brain Network Responses Using Intracranial Electrophysiological Recordings

TypeinterventionalSponsorUniversity of PennsylvaniaRan2026 to 2031Enrolled30ConditionsLow Intensity Focussed Ultrasound, Electrodes, ImplantedArmsLow Intensity Focused Ultrasound
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Joshua A CainDepartment of Psychology, University of California Los Angeles, Pritzker Hall, Los Angeles, CA, 90095, USA. joshcain@ucla.edu.
Shakthi VisaganDepartment of Neurology, University of California Los Angeles, Los Angeles, 90095, USA.
Micah A JohnsonDepartment of Psychology, University of California Los Angeles, Pritzker Hall, Los Angeles, CA, 90095, USA.
Julia CroneDepartment of Psychology, University of California Los Angeles, Pritzker Hall, Los Angeles, CA, 90095, USA.
Robin BladesDepartment of Psychology, University of California Los Angeles, Pritzker Hall, Los Angeles, CA, 90095, USA.
Norman M SpivakDepartment of Psychiatry, University of California Los Angeles, Los Angeles, 90095, USA.
David W ShattuckDepartment of Neurology, University of California Los Angeles, Los Angeles, 90095, USA.
Martin M MontiDepartment of Psychology, University of California Los Angeles, Pritzker Hall, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · US

Funding

Interactive software for semiautomated analysis of structural brain imagesR01NS074980 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEAHY, RICHARD M, SHATTUCK, DAVID W · 2011 to 2021
$5.0M
NINDS NIH HHS R01 NS074980
6 · The paper itself

Abstract

Deep brain nuclei are integral components of large-scale circuits mediating important cognitive and sensorimotor functions. However, because they fall outside the domain of conventional non-invasive neuromodulatory techniques, their study has been primarily based on neuropsychological models, limiting the ability to fully characterize their role and to develop interventions in cases where they are damaged. To address this gap, we used the emerging technology of non-invasive low-intensity focused ultrasound (LIFU) to directly modulate left lateralized basal ganglia structures in healthy volunteers. During sonication, we observed local and distal decreases in blood oxygenation level dependent (BOLD) signal in the targeted left globus pallidus (GP) and in large-scale cortical networks. We also observed a generalized decrease in relative perfusion throughout the cerebrum following sonication. These results show, for the first time using functional MRI data, the ability to modulate deep-brain nuclei using LIFU while measuring its local and global consequences, opening the door for future applications of subcortical LIFU.

Indexed as

Globus PallidusMagnetic Resonance ImagingUltrasonic TherapyAdolescentAdultFemaleHumansMale

Identifiers

PMID33731821
PMCPMC7969624
OpenAlexW3137210308

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.