ArticleScientific reports2021
Adaptive constrained constructive optimisation for complex vascularisation processes.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 51 citations in OpenAlex.
- Stochastic numerical head phantoms to enable virtual imaging studies of transcranial photoacoustic computed tomography.Photoacoustics · 2026Article
- Hierarchy Aware CT-Driven Constrained Constructive Optimization: A Framework for Coronary Network Generation.Annals of biomedical engineering · 2026Article
- "MR Fingerprinting for Imaging Brain Hemodynamics and Oxygenation".Journal of magnetic resonance imaging : JMRI · 2025Review
- Computational Framework for Modeling Effects of Brain Collateral Circulation.International journal for numerical methods in biomedical engineering · 2025Article
- Multiscale Coronary Arterial Network Generation and Hemodynamics Using Patient-Specific Fractional Myocardial Blood Volume.Bioengineering (Basel, Switzerland) · 2025Article
- Multicompartment Darcy Flow Model With Patient-Specific Parameterization: Effect of Heterogeneity and Anisotropy in Porous Parameters.International journal for numerical methods in biomedical engineering · 2025Article
- Blood flow in the human cerebral cortex: Large-scale pial vascularization and 1D simulation.PLoS computational biology · 2025Article
- Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing.Science (New York, N.Y.) · 2025Article
- Fast aberration correction in 3D transcranial photoacoustic computed tomography via a learning-based image reconstruction method.Photoacoustics · 2025Article
- A simplified computational liver perfusion model, with applications to organ preservation.Scientific reports · 2025Article
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- Linking Vascular Structure and Function: Image-Based Virtual Populations of the Retina.Investigative ophthalmology & visual science · 2024Article
- Enhanced perfusion following exposure to radiotherapy: A theoretical investigation.PLoS computational biology · 2024Article
- Enhancing MR vascular Fingerprinting with realistic microvascular geometries.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Approaches to vascular network, blood flow, and metabolite distribution modeling in brain tissue.Biophysical reviews · 2023Review
- A Hybrid Model for Cardiac Perfusion: Coupling a Discrete Coronary Arterial Tree Model with a Continuous Porous-Media Flow Model of the Myocardium.Entropy (Basel, Switzerland) · 2023Article
- The growth of capillary networks by branching for maximum fluid access.Scientific reports · 2023Article
- Tissue-growth-based synthetic tree generation and perfusion simulation.Biomechanics and modeling in mechanobiology · 2023Article
- Computational models for generating microvascular structures: Investigations beyond medical imaging resolution.WIREs mechanisms of disease · 2023Review
- Mechanical regulation of the early stages of angiogenesis.Journal of the Royal Society, Interface · 2022Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mimicking angiogenetic processes in vascular territories acquires importance in the analysis of the multi-scale circulatory cascade and the coupling between blood flow and cell function. The present work extends, in several aspects, the Constrained Constructive Optimisation (CCO) algorithm to tackle complex automatic vascularisation tasks. The main extensions are based on the integration of adaptive optimisation criteria and multi-staged space-filling strategies which enhance the modelling capabilities of CCO for specific vascular architectures. Moreover, this vascular outgrowth can be performed either from scratch or from an existing network of vessels. Hence, the vascular territory is defined as a partition of vascular, avascular and carriage domains (the last one contains vessels but not terminals) allowing one to model complex vascular domains. In turn, the multi-staged space-filling approach allows one to delineate a sequence of biologically-inspired stages during the vascularisation process by exploiting different constraints, optimisation strategies and domain partitions stage by stage, improving the consistency with the architectural hierarchy observed in anatomical structures. With these features, the aDaptive CCO (DCCO) algorithm proposed here aims at improving the modelled network anatomy. The capabilities of the DCCO algorithm are assessed with a number of anatomically realistic scenarios.
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