Evidence map›Paper›PMID 33731771›Full record

SynthesisScientific reports2021

Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity.

María Isabel Iñiguez-Luna, Jorge Cadena-Iñiguez, Ramón Marcos Soto-Hernández, Francisco Javier Morales-Flores, Moisés Cortes-Cruz, Kazuo N Watanabe, Ryoko Machida-Hirano, Jorge David Cadena-Zamudio

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Foods (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Biotechnological Potential ofBiotech (Basel (Switzerland)) · 2026
    Article
  4. The Bioprospecting ofMetabolites · 2025
    Review
  5. Genotypes ofLife (Basel, Switzerland) · 2024
    Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

María Isabel Iñiguez-LunaPostgrado de Innovación en Manejo de Recursos Naturales Colegio de Posgraduados, Campus San Luis Potosí, Salinas de Hidalgo, Iturbide 73, 78620, San Luis Potosí, Mexico.ORCID 0000-0002-2017-429X
Jorge Cadena-IñiguezPostgrado de Innovación en Manejo de Recursos Naturales Colegio de Posgraduados, Campus San Luis Potosí, Salinas de Hidalgo, Iturbide 73, 78620, San Luis Potosí, Mexico. jocadena@gmail.com.ORCID 0000-0002-6427-0646
Ramón Marcos Soto-HernándezPrograma de Botánica Colegio de Postgraduados, Km. 36.5 Carretera México-Texcoco, 56230, Texcoco, Estado de México, Mexico. msoto@colpos.mx.ORCID 0000-0001-8577-7991
Francisco Javier Morales-FloresPostgrado de Innovación en Manejo de Recursos Naturales Colegio de Posgraduados, Campus San Luis Potosí, Salinas de Hidalgo, Iturbide 73, 78620, San Luis Potosí, Mexico.ORCID 0000-0002-4919-1536
Moisés Cortes-CruzCentro Nacional de Recursos Genéticos-INIFAP, Boulevard de la Biodiversidad 300, 47600, Tepatitlán de Morelos, Jalisco, Mexico.ORCID 0000-0001-7399-0090
Kazuo N WatanabeTsukuba Plant Innovation Research Center, University of Tsukuba, Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki Prefecture, 305-8571, Japan.ORCID 0000-0003-4350-0139
Ryoko Machida-HiranoGenetic Resources Center, National Agriculture and Food Research Organization, 2-1-2 Kannondai, Tsukuba, Ibaraki, 305-8602, Japan.ORCID 0000-0002-7978-0235
Jorge David Cadena-ZamudioGrupo Interdisciplinario de Investigación en Sechium edule en México, A.C. Agustín Melgar 10 Col. Niños Héroes, 56108, Texcoco, Estado de México, Mexico.ORCID 0000-0002-2855-4561
Autonomous University of San Luis Potosí · MXEl Colegio de México · MXInstituto de Ecología · MXInstituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias · MXNational Agriculture and Food Research Organization · JPUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioprospecting identifies new sources of compounds with actual or potential economic value that come from biodiversity. An analysis was performed regarding bioprospecting purposes in ten genotypes of Sechium spp., through a meta-analysis of 20 information sources considering different variables: five morphological, 19 biochemical, anti-proliferative activity of extracts on five malignant cell lines, and 188 polymorphic bands of amplified fragment length polymorphisms, were used in order to identify the most relevant variables for the design of genetic interbreeding. Significant relationships between morphological and biochemical characters and anti-proliferative activity in cell lines were obtained, with five principal components for principal component analysis (SAS/ETS); variables were identified with a statistical significance (< 0.7 and Pearson values ≥ 0.7), with 80.81% of the accumulation of genetic variation and 110 genetic bands. Thirty-nine (39) variables were recovered using NTSYSpc software where 30 showed a Pearson correlation (> 0.5) and nine variables (< 0.05), Finally, using a cladistics analysis approach highlighted 65 genetic bands, in addition to color of the fruit, presence of thorns, bitter flavor, piriform and oblong shape, and also content of chlorophylls a and b, presence of cucurbitacins, and the IC

Indexed as

BioprospectingCucurbitaceaeAnimalsCell LineCucurbitacinsFruitGenotypeHumansMicePlant ExtractsPolymorphism, GeneticCucurbitacinsPlant Extracts

Identifiers

PMID33731771
PMCPMC7969600
OpenAlexW3137183747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.