ArticleScientific reports2021
Repetitive transcranial magnetic stimulation restores altered functional connectivity of central poststroke pain model monkeys.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Transcranial magnetic stimulation therapy for central post-stroke pain: systematic review and meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Central Post-Stroke Pain: An Integrative Review of Somatotopic Damage, Clinical Symptoms, and Neurophysiological Measures.Frontiers in neurology · 2021Pooled it
- Development of repetitive transcranial magnetic stimulation for central poststroke pain: A review.Medicine · 2025Review
- Central post-stroke pain: advances in clinical and preclinical research.Stroke and vascular neurology · 2025Review
- What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Role of Brain Derived Neurotrophic Factor and Related Therapeutic Strategies in Central Post-Stroke Pain.Neurochemical research · 2024Review
- Brain activity changes after high/low frequency stimulation in a nonhuman primate model of central post-stroke pain.Scientific reports · 2024Article
- Neurocircuitry basis of motor cortex-related analgesia as an emerging approach for chronic pain management.Nature. Mental health · 2024Article
- Beyond trial-and-error: Individualizing therapeutic transcranial neuromodulation for chronic pain.European journal of pain (London, England) · 2023Review
- Repetitive transcranial magnetic stimulation in central post-stroke pain: current status and future perspective.The Korean journal of pain · 2023Review
- Role of Sensory Pathway Injury in Central Post-Stroke Pain: A Narrative Review of Its Pathogenetic Mechanism.Journal of pain research · 2023Review
- Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke.Frontiers in neuroscience · 2023Review
- Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation.Brain : a journal of neurology · 2022Review
- Cortical stimulation for chronic pain: from anecdote to evidence.European journal of physical and rehabilitation medicine · 2022Review
- Insight Into the Effects of Clinical Repetitive Transcranial Magnetic Stimulation on the Brain From Positron Emission Tomography and Magnetic Resonance Imaging Studies: A Narrative Review.Frontiers in neuroscience · 2022Review
- Dissecting central post-stroke pain: a controlled symptom-psychophysical characterization.Brain communications · 2022Article
- Research Hotspots and Frontiers in Post Stroke Pain: A Bibliometric Analysis Study.Frontiers in molecular neuroscience · 2022Article
- The mechanism and effect of repetitive transcranial magnetic stimulation for post-stroke pain.Frontiers in molecular neuroscience · 2022Review
- Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke.Frontiers in systems neuroscience · 2021Review
- Neuromodulation approaches and applications in the management of post-stroke pain: a comprehensive review.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central poststroke pain (CPSP) develops after a stroke around the somatosensory pathway. CPSP is hypothesized to be caused by maladaptive reorganization between various brain regions. The treatment for CPSP has not been established; however, repetitive transcranial magnetic stimulation (rTMS) to the primary motor cortex has a clinical effect. To verify the functional reorganization hypothesis for CPSP development and rTMS therapeutic mechanism, we longitudinally pursued the structural and functional changes of the brain by using two male CPSP model monkeys (Macaca fuscata) developed by unilateral hemorrhage in the ventral posterolateral nucleus of the thalamus. Application of rTMS to the ipsilesional primary motor cortex relieved the induced pain of the model monkeys. A tractography analysis revealed a decrease in the structural connectivity in the ipsilesional thalamocortical tract, and rTMS had no effect on the structural connectivity. A region of interest analysis using resting-state functional magnetic resonance imaging revealed inappropriately strengthened functional connectivity between the ipsilesional mediodorsal nucleus of the thalamus and the amygdala, which are regions associated with emotion and memory, suggesting that this may be the cause of CPSP development. Moreover, rTMS normalizes this strengthened connectivity, which may be a possible therapeutic mechanism of rTMS for CPSP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.