ArticleScientific reports2021
Temperate conditions restrict Japanese encephalitis virus infection to the mid-gut and prevents systemic dissemination in Culex pipiens mosquitoes.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Mosquito vector competence for Japanese encephalitis virus: a systematic review and meta-analysis update.Parasites & vectors · 2025Pooled it
- Identification and mapping of potential and highly likely vectors for selected vector-borne diseases in the EU and neighbouring countries.EFSA journal. European Food Safety Authority · 2026Article
- Evaluation of vector competence of Culex tritaeniorhynchus and Culex pipiens pallens for Japanese encephalitis virus genotype III and V.Parasites & vectors · 2025Article
- Mosquito populations originating from nonendemic areas have the potential to transmit recently emerging Japanese encephalitis virus genotype IV.Emerging microbes & infections · 2025Article
- Genetic shifts of Japanese encephalitis virus (JEV) in mosquitoes in the Republic of Korea, 2017-2022.PLoS neglected tropical diseases · 2025Article
- Evidence of Transmission Capability in UKViruses · 2025Article
- Epidemiological Features, Clinical Symptoms, and Environmental Risk Factors for Notifiable Japanese Encephalitis in Taiwan From 2008 to 2020: Retrospective Study.JMIR public health and surveillance · 2025Article
- Unique humoral immune response of pigs to repeated natural Japanese encephalitis virus infections: an amplifying host perspective.Archives of virology · 2025Article
- European Preparedness for Japanese Encephalitis Virus Through Alignment of Animal Health Laboratory Diagnosis.Transboundary and emerging diseases · 2025Article
- Vector competence of EuropeanCurrent research in parasitology & vector-borne diseases · 2025Article
- Spatial distribution and environmental correlations of Culex pipiens pallens (Diptera: Culicidae) in Haidian district, Beijing.Journal of medical entomology · 2024Article
- Vector competence of Swedish Culex pipiens mosquitoes for Japanese encephalitis virus.Parasites & vectors · 2024Article
- BelgianMicroorganisms · 2023Article
- Article
- Article
- Modelling the Potential Human Exposure to Japanese Encephalitis Virus (JEV) in Case of Introduction into Reunion Island.Transboundary and emerging diseases · 2023Article
- Article
- Susceptibility of Aedes albopictus and Culex quinquefasciatus to Japanese encephalitis virus.Parasites & vectors · 2022Article
- Article
- Japanese Encephalitis Virus Interaction with Mosquitoes: A Review of Vector Competence, Vector Capacity and Mosquito Immunity.Pathogens (Basel, Switzerland) · 2022Review
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9 authors at 3 institutions in 1 country.
Funding
Abstract
Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is the main cause of viral encephalitis in Asia. However, with changing climate JEV has the potential to emerge in novel temperate regions. Here, we have assessed the vector competence of the temperate mosquito Culex pipiens f. pipiens to vector JEV genotype III at temperatures representative of those experienced, or predicted in the future during the summer months, in the United Kingdom. Our results show that Cx. pipiens is susceptible to JEV infection at both temperatures. In addition, at 25 °C, JEV disseminated from the midgut and was recovered in saliva samples, indicating the potential for transmission. At a lower temperature, 20 °C, following an incubation period of fourteen days, there were reduced levels of JEV dissemination and virus was not detected in saliva samples. The virus present in the bodies of these mosquitoes was restricted to the posterior midgut as determined by microscopy and viable virus was successfully recovered. Apart from the influence on virus dissemination, mosquito mortality was significantly increased at the higher temperature. Overall, our results suggest that temperature is a critical factor for JEV vector competence and infected-mosquito survival. This may in turn influence the vectorial capacity of Cx. pipiens to vector JEV genotype III in temperate areas.
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