ArticleScientific reports2021
Vaginal microbiome and serum metabolite differences in late gestation commercial sows at risk for pelvic organ prolapse.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Unraveling the relationship between the vaginal microbiome and return to estrus in post-weaning sows.BMC veterinary research · 2026Article
- Evaluation of vaginal ampicillin administration in late gestation sows on pelvic organ prolapse in relation to perineal score and litter characteristics.Translational animal science · 2026Article
- Evaluation of antibiotic usage during late gestation on pelvic organ prolapse incidence in sows.Translational animal science · 2026Article
- Sperm Quality and Welfare of Sexually Mature Boars Supplemented with Partially Fermentable Insoluble Fiber.Life (Basel, Switzerland) · 2025Article
- Divergence in the sow vaginal microbiota is associated with fertility.Reproduction (Cambridge, England) · 2025Article
- Combined analysis of 16S rRNA gene sequencing data reveals core vaginal bacteria across livestock species.Frontiers in microbiology · 2025Article
- Evaluation of fecal microbiota of late gestation sows in relation to pelvic organ prolapse risk.Frontiers in microbiology · 2024Article
- Benefits of maternal pectin supplementation in gestation diet on vaginal microbiota of sows and intestinal health of newborn piglets.Frontiers in veterinary science · 2024Article
- Too late or too soon? The replacement gilt paradox.Animal reproduction · 2024Review
- Managing Reproduction in Hyperprolific Sow Herds.Animals : an open access journal from MDPI · 2023Review
- Current practice in animal models for pelvic floor dysfunction.International urogynecology journal · 2023Review
- Identification of the genetic basis of sow pelvic organ prolapse.Frontiers in genetics · 2023Article
- Untargeted Metabolomics Pilot Study Using UHPLC-qTOF MS Profile in Sows' Urine Reveals Metabolites of Bladder Inflammation.Metabolites · 2022Article
- Vaginal microbiota signatures in healthy and purulent vulvar discharge sows.Scientific reports · 2022Article
- Vaginal microbiota differences associated with pelvic organ prolapse risk during late gestation in commercial sows†.Biology of reproduction · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sow mortality attributable to pelvic organ prolapse (POP) has increased in the U.S. swine industry and continues to worsen. Two main objectives of this study were, (1) to develop a perineal scoring system that can be correlated with POP risk, and (2) identify POP risk-associated biological factors. To assess POP risk during late gestation, sows (n = 213) were scored using a newly developed perineal scoring (PS) system. Sows scored as PS1 (low), PS2 (moderate), or PS3 (high) based on POP risk. Subsequently, 1.5, 0.8, and 23.1% of sows scored PS1, PS2, or PS3, respectively, experienced POP. To identify biomarkers, serum and vaginal swabs were collected from late gestation sows differing in PS. Using GC-MS, 82 serum metabolite differences between PS1 and PS3 animals (P < 0.05) were identified. Vaginal swabs were utilized for 16S rRNA gene sequencing and differences in vaginal microbiomes between PS1 and PS3 animals were detected on a community level (P < 0.01) along with differences in abundances of 89 operational taxonomic units (P < 0.05). Collectively, these data demonstrate that sows with greater POP risk have differential serum metabolites and vaginal microflora. Additionally, an initial and novel characterization of the sow vaginal microbiome was determined.
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