Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 2 institutions in 2 countries.
Daniela Egli-SpichtigDivision of Nephrology, Department of Pediatrics, University of California San Francisco, San Francisco, USA.
Martin Y H ZhangDivision of Nephrology, Department of Pediatrics, University of California San Francisco, San Francisco, USA.
Alfred LiDepartment of Medicine, San Francisco Veterans Affairs Medical Center (VAMC), University of California San Francisco, San Francisco, USA.
Eva Maria Pastor ArroyoInstitute of Physiology, University of Zurich, Zurich Switzerland and National Center of Competence in Research NCCR Kidney.CH, Zurich, Switzerland.
Nati HernandoInstitute of Physiology, University of Zurich, Zurich Switzerland and National Center of Competence in Research NCCR Kidney.CH, Zurich, Switzerland.
Carsten A WagnerInstitute of Physiology, University of Zurich, Zurich Switzerland and National Center of Competence in Research NCCR Kidney.CH, Zurich, Switzerland.
Wenhan ChangDepartment of Medicine, San Francisco Veterans Affairs Medical Center (VAMC), University of California San Francisco, San Francisco, USA.
Farzana PerwadDivision of Nephrology, Department of Pediatrics, University of California San Francisco, San Francisco, USA. farzana.perwad@ucsf.edu.
University of California, San Francisco · USUniversity of Zurich · CH
Funding
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2014 to 2018
$3.0M
Regulation of Parathyroid Functions By G-Protein Coupled ReceptorsR01DK122259 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI CHANG, WENHAN, VILARDAGA, JEAN-PIERRE · 2019 to 2023
$2.2M
BLRD Research Career Scientist Award ApplicationIK6BX004835 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI Wenhan Chang · 2020 to 2026
–
BLRD VA I01 BX005851BLRD VA IK6 BX004835NIAMS NIH HHS P30 AR066262NIAMS NIH HHS P30 AR075055NIDDK NIH HHS R01 DK122259
6 · The paper itself
Abstract
Fibroblast growth factor 23 (FGF23) is a bone-derived endocrine hormone that regulates phosphate and vitamin D metabolism. In models of FGF23 excess, renal deoxyribonuclease 1 (Dnase1) mRNA expression is downregulated. Dnase-1 is an endonuclease which binds monomeric actin. We investigated whether FGF23 suppresses renal Dnase-1 expression to facilitate endocytic retrieval of renal sodium dependent phosphate co-transporters (NaPi-IIa/c) from the brush border membrane by promoting actin polymerization. We showed that wild type mice on low phosphate diet and Fgf23
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling. · full record | OpenQuestion