ArticleTranslational psychiatry2021
White matter microstructure and its relation to clinical features of obsessive-compulsive disorder: findings from the ENIGMA OCD Working Group.
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Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
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32citing papers in PubMed, 5 pooled it
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Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Serotonergic underpinnings of obsessive-compulsive disorder: A systematic review and meta-analysis of neuroimaging findings.Psychiatry and clinical neurosciences · 2025Pooled it
- White matter abnormalities in paediatric obsessive-compulsive disorder: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2023Pooled it
- Role of White Matter Microstructure in Impulsive Behavior.The Journal of neuropsychiatry and clinical neurosciences · 2022Pooled it
- Microstructural white matter abnormalities in pediatric and adult obsessive-compulsive disorder: A systematic review and meta-analysis.Brain and behavior · 2021Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Altered frontal and occipital cortical microstructure in obsessive-compulsive disorder - a multisite mega-analysis.Molecular psychiatry · 2026Article
- Medial prefrontal-thalamic white matter microstructure is associated with harm avoidance in OCD: a discovery and transdiagnostic replication study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Differences in cortical gyrification and fractional amplitude of low-frequency fluctuations between early- and late-onset obsessive-compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2026Article
- Widespread alterations of white matter integrity in medication-free obsessive-compulsive disorder.Translational psychiatry · 2025Article
- Pre-CBT resting-state connectivity and white matter integrity in OCD remission: A multimodal MRI study.Neuroimage. Reports · 2025Article
- Examining relationships among NODDI indices of white matter structure in prefrontal cortical-thalamic-striatal circuitry and OCD symptomatology.Translational psychiatry · 2024Article
- A worldwide study of white matter microstructural alterations in people living with Parkinson's disease.NPJ Parkinson's disease · 2024Article
- White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group.Molecular psychiatry · 2024Article
- Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure.Molecular psychiatry · 2024Article
- A systematic review of structural neuroimaging markers of psychotherapeutic and pharmacological treatment for obsessive-compulsive disorder.Frontiers in psychiatry · 2024Review
- In search of environmental risk factors for obsessive-compulsive disorder: study protocol for the OCDTWIN project.BMC psychiatry · 2023Article
- In search of environmental risk factors for obsessive-compulsive disorder: Study protocol for the OCDTWIN project.Research square · 2023Article
- Deep clinical phenotyping of patients with obsessive-compulsive disorder: an approach towards detection of organic causes and first results.Translational psychiatry · 2023Article
- Abnormal focal segments in left uncinate fasciculus in adults with obsessive-compulsive disorder.Frontiers in psychiatry · 2023Article
- Dysfunctional Beliefs and Cognitive Performance across Symptom Dimensions in Childhood and Adolescent OCD.Journal of clinical medicine · 2022Article
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Authors and funding
59 authors at 20 institutions in 15 countries.
Fabrizio PirasLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. f.piras@hsantalucia.it.ORCID 0000-0003-3566-5494
Federica PirasLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Yoshinari AbeDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID 0000-0001-8348-0801
Sri Mahavir AgarwalObsessive-Compulsive Disorder (OCD) Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
Alan AnticevicDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Stephanie AmeisChild, Youth and Emerging Adult Program, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Paul ArnoldMathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-2496-4624
Nerisa BanajLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Núria BargallóMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Marcelo C BatistuzzoInstituto e Departamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID 0000-0003-1347-8241
Francesco BenedettiPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy.ORCID 0000-0003-4949-856X
Jan-Carl BeuckeDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Premika S W BoedhoeAmsterdam University Medical Centers, Vrije Universiteit, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Irene BollettiniPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy.
Silvia BremDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Anna CalvoMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Kang Ik Kevin ChoInstitute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
Valentina CiulloLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Sara DallaspeziaPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy.
Erin DickieCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID 0000-0003-3028-9864
Benjamin Adam ElyDepartment of Neuroscience and Graduate School, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3019-0090
Siyan FanAmsterdam university medical centers, Vrije Universiteit, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Jean-Paul FoucheSAMRC Unit on Anxiety & Stress Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Patricia GrunerDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Deniz A GürselDepartment of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Tobias HauserAmsterdam university medical centers, Vrije Universiteit, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands.ORCID 0000-0002-7997-8137
Yoshiyuki HiranoResearch Center for Child Mental Development, Chiba University, Chiba, Japan.ORCID 0000-0003-3844-3061
Marcelo Q HoexterInstituto e Departamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Mariangela IorioLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
Anthony JamesDepartment of Psychiatry, Oxford University, Oxford, UK.ORCID 0000-0002-2742-8328
Y C Janardhan ReddyObsessive-Compulsive Disorder (OCD) Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
Christian KaufmannDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Kathrin KochDepartment of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Peter KochunovMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3656-4281
Jun Soo KwonInstitute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.ORCID 0000-0002-1060-1462
Luisa LazaroDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain.
Christine LochnerSAMRC Unit on Anxiety & Stress Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Rachel MarshColumbia University Irving Medical Center, Columbia University, New York, NY, USA.
Akiko NakagawaResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Takashi NakamaeDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID 0000-0003-4265-198X
Janardhanan C NarayanaswamyObsessive-Compulsive Disorder (OCD) Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.
Yuki SakaiDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID 0000-0003-2475-8548
Eiji ShimizuResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Daniela SimonDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Helen Blair SimpsonColumbia University Irving Medical Center, Columbia University, New York, NY, USA.
Noam SoreniPediatric OCD Consultation Clinic, Anxiety Treatment and Research Center, McMaster University, Hamilton, Ontario, Canada.
Philipp StämpfliMR-Center of the Department of Psychiatry, Psychotherapy and Psychosomatics and the Department of Child and Adolescent Psychiatry, Psychiatric Hospital of the University of Zurich, Zurich, Switzerland.
Emily R SternDepartment of Neuroscience and Graduate School, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Philip SzeszkoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jumpei TakahashiResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Ganesan VenkatasubramanianObsessive-Compulsive Disorder (OCD) Clinic, Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India.ORCID 0000-0002-0949-898X
Zhen WangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.ORCID 0000-0003-4319-5314
Je-Yeon YunInstitute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.ORCID 0000-0002-5531-2410
ENIGMA OCD Working Group
Dan J SteinSAMRC Unit on Anxiety & Stress Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7218-7810
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, USA.
Odile A van den HeuvelAmsterdam University Medical Centers, Vrije Universiteit, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Gianfranco SpallettaLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy. g.spalletta@hsantalucia.it.
Fondazione Santa Lucia · ITCenter for Forensic Mental Health, Chiba University · JPIRCCS Ospedale San Raffaele · ITAmsterdam Neuroscience · NLHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRNational Institute of Mental Health and Neurosciences · INSouth African Medical Research Council · ZAUniversity of Zurich · CHYale University · USIcahn School of Medicine at Mount Sinai · USKyoto Prefectural University of Medicine · JPBaylor College of Medicine · USCentre for Addiction and Mental Health · CAColumbia University Irving Medical Center · USHumboldt-Universität zu Berlin · DETUM Klinikum · DEUniversity of Southern California · USWarneford Hospital · GBCentro de Investigación Biomédica en Red de Salud Mental · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ES
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1MDissecting Causal Reasoning Abnormalities in Obsessive-Compulsive Disorder (OCD)K23MH115206 · NIMH · YALE UNIVERSITY · PI GRUNER, PATRICIA A. · 2018 to 2021
$788kNCATS NIH HHS UL1 TR001863NIBIB NIH HHS P41 EB015922NIMH NIH HHS K23 MH115206
Abstract
Microstructural alterations in cortico-subcortical connections are thought to be present in obsessive-compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power to detect subtle abnormalities. Here we investigated microstructural white matter alterations and their relation to clinical features in the largest dataset of adult and pediatric OCD to date. We analyzed diffusion tensor imaging metrics from 700 adult patients and 645 adult controls, as well as 174 pediatric patients and 144 pediatric controls across 19 sites participating in the ENIGMA OCD Working Group, in a cross-sectional case-control magnetic resonance study. We extracted measures of fractional anisotropy (FA) as main outcome, and mean diffusivity, radial diffusivity, and axial diffusivity as secondary outcomes for 25 white matter regions. We meta-analyzed patient-control group differences (Cohen's d) across sites, after adjusting for age and sex, and investigated associations with clinical characteristics. Adult OCD patients showed significant FA reduction in the sagittal stratum (d = -0.21, z = -3.21, p = 0.001) and posterior thalamic radiation (d = -0.26, z = -4.57, p < 0.0001). In the sagittal stratum, lower FA was associated with a younger age of onset (z = 2.71, p = 0.006), longer duration of illness (z = -2.086, p = 0.036), and a higher percentage of medicated patients in the cohorts studied (z = -1.98, p = 0.047). No significant association with symptom severity was found. Pediatric OCD patients did not show any detectable microstructural abnormalities compared to controls. Our findings of microstructural alterations in projection and association fibers to posterior brain regions in OCD are consistent with models emphasizing deficits in connectivity as an important feature of this disorder.
Indexed as
Obsessive-Compulsive DisorderWhite MatterAdultAnisotropyBrainChildCross-Sectional StudiesDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingHumans
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