ReviewBiomolecules & therapeutics2021
Recent Advances of Therapeutic Targets for the Treatment of Periodontal Disease.
Review in Biomolecules & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Laser Therapy Effects on Periodontal Status: A Randomized Study Using Gaussian Network Analysis and Structural Equation Modeling Approach.Medicina (Kaunas, Lithuania) · 2024Trial
- Evaluation of Saussurea costus Nanoparticles in the Treatment of Periodontitis: Impact on NF-κB and TNF-α Expression.European journal of dentistry · 2026Article
- Exploring the Therapeutic Potential of Diverse Bacterial Strains for Management of Periodontal Diseases.Probiotics and antimicrobial proteins · 2026Review
- Dimensionally Engineered Nanotherapeutics for Pulpitis and Periodontitis: From Structural Design to Artificial Intelligence-Enabled Precision Therapy.International journal of nanomedicine · 2026Review
- Mesenchymal stem cell-derived apoptotic vesicles: emerging cell-free strategy for periodontitis treatment.Journal of nanobiotechnology · 2025Review
- Histological Assessment of the Anti-Inflammatory Effectiveness of Peperomia pellucida Extract Administered to the Gingival Sulcus in Rats Induced with Periodontitis.European journal of dentistry · 2025Article
- An Artificial Intelligence-Based Fuzzy Logic System for Periodontitis Risk Assessment in Patients with Type 2 Diabetes Mellitus.Bioengineering (Basel, Switzerland) · 2025Article
- Anti-inflammatory effectiveness ofBiochemistry and biophysics reports · 2024Article
- Review
- Acceleration of HDL-Mediated Cholesterol Efflux Alleviates Periodontitis.Journal of dental research · 2024Article
- Exploring the Efficacy of Novel Therapeutic Strategies for Periodontitis: A Literature Review.Life (Basel, Switzerland) · 2024Review
- New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration.Journal of nanobiotechnology · 2024Review
- Application of Nanomaterials Targeting Immune Cells in the Treatment of Chronic Inflammation.International journal of nanomedicine · 2024Review
- Nanosystems for modulation of immune responses in periodontal therapy: a mini-review.Frontiers in dental medicine · 2024Review
- Periodontal disease in down syndrome: Predisposing factors and potential non-surgical therapeutic approaches.Journal of clinical laboratory analysis · 2024Review
- Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters.International journal of molecular sciences · 2023Article
- Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss.Experimental & molecular medicine · 2023Article
- Review
- Therapeutic effect of aged garlic extract on gingivitis in dogs.Frontiers in veterinary science · 2023Article
- Drugs for the Quorum Sensing Inhibition of Oral Biofilm: New Frontiers and Insights in the Treatment of Periodontitis.Pharmaceutics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease is primarily associated with bacterial infection such as dental plaque. Dental plaque, an oral biofilm harboring a complex microbial community, can cause various inflammatory reactions in periodontal tissue. In many cases, the local bacterial invasion and host-mediated immune responses lead to severe alveolar bone destruction. To date, plaque control, non-surgical, and surgical interventions have been the conventional periodontal treatment modalities. Although adjuvant therapies including antibiotics or supplements have accompanied these procedures, their usage has been limited by antibiotic resistance, as well as their partial effectiveness. Therefore, new strategies are needed to control local inflammation in the periodontium and host immune responses. In recent years, target molecules that modulate microbial signaling mechanisms, host inflammatory substances, and bone immune responses have received considerable attention by researchers. In this review, we introduce three approaches that suggest a way forward for the development of new treatments for periodontal disease; (1) quorum quenching using quorum sensing inhibitors, (2) inflammasome targeting, and (3) use of FDA-approved anabolic agents, including Teriparatide and sclerostin antibody.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.