Evidence map›Paper›PMID 33731454›Full record

ArticleJournal of virology2021

BRD4S interacts with viral E2 protein to limit human papillomavirus late transcription.

A Yigitliler, J Renner, C Simon, M Schneider, F Stubenrauch, T Iftner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

A YigitlilerInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, University of Tuebingen, D72076 Tuebingen, Germany.
J RennerInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, University of Tuebingen, D72076 Tuebingen, Germany.
C SimonInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, University of Tuebingen, D72076 Tuebingen, Germany.ORCID https://orcid.org/0000-0003-1976-5305
M SchneiderInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, University of Tuebingen, D72076 Tuebingen, Germany.
F StubenrauchInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, University of Tuebingen, D72076 Tuebingen, Germany.ORCID https://orcid.org/0000-0002-6685-299X
T IftnerInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, University of Tuebingen, D72076 Tuebingen, Germany thomas.iftner@med.uni-tuebingen.de.ORCID https://orcid.org/0000-0002-5929-7078
University of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The E2 protein encoded by human papillomaviruses (HPV) is a sequence-specific DNA-binding protein that recruits viral and cellular proteins. Bromodomain-containing protein 4 (BRD4) is a highly conserved interactor for E2 proteins that has been linked to E2's functions as transcription modulator, activator of viral replication and segregation factor for viral genomes. In addition to BRD4, a short form of BRD4 (BRD4S) is expressed from the

Identifiers

PMID33731454
PMCPMC8139696
OpenAlexW3138621958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.