Evidence map›Paper›PMID 33731446›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Reduced Repetition Suppression in Aging is Driven by Tau-Related Hyperactivity in Medial Temporal Lobe.

Jenna N Adams, Anne Maass, David Berron, Theresa M Harrison, Suzanne L Baker, Wesley P Thomas, Morgan Stanfill, William J Jagust

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Synergistic effects ofbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Entorhinal-Hippocampal Circuit Integrity Is Related to Mnemonic Discrimination and Amyloid-β Pathology in Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Distinct Factors Drive the Spatiotemporal Progression of Tau Pathology in Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Jenna N AdamsHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 jnadams@berkeley.edu.ORCID 0000-0002-6702-3851
Anne MaassHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720.
David BerronGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg 39120, Germany.ORCID 0000-0003-1558-1883
Theresa M HarrisonHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720.
Suzanne L BakerLawrence Berkeley National Laboratory, Berkeley, California 94720.ORCID 0000-0003-0209-3127
Wesley P ThomasLawrence Berkeley National Laboratory, Berkeley, California 94720.
Morgan StanfillHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720.
William J JagustHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720.ORCID 0000-0002-4458-113X
Lawrence Berkeley National Laboratory · USUniversity of California, Berkeley · USGerman Center for Neurodegenerative Diseases · DELund University · SE

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Neuroscience Training Program at UC BerkeleyT32NS095939 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BATEUP, HELEN S. · 2016 to 2025
$6.3M
Tracking Tau with In Vivo Braak Staging: Longitudinal Analysis of Tau Pathology and Functional Sequelae in Cognitively Healthy Older AdultsF32AG057107 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRISON, THERESA M. · 2017 to 2020
$124k
Tracking tau spread through functional connectivity networks in agingF31AG062090 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI ADAMS, JENNA NICOLE · 2019 to 2020
$63k
NIA NIH HHS F31 AG062090NIA NIH HHS F32 AG057107NIA NIH HHS R01 AG034570NINDS NIH HHS T32 NS095939
6 · The paper itself

Abstract

Tau deposition begins in the medial temporal lobe (MTL) in aging and Alzheimer's disease (AD), and MTL neural dysfunction is commonly observed in these groups. However, the association between tau and MTL neural activity has not been fully characterized. We investigated the effects of tau on repetition suppression, the reduction of activity for repeated stimulus presentations compared to novel stimuli. We used task-based functional MRI (fMRI) to assess MTL subregional activity in 21 young adults (YA) and 45 cognitively normal human older adults (OA; total sample: 37 females, 29 males). AD pathology was measured with position emission tomography (PET), using

Indexed as

AgedAged, 80 and overAgingAlzheimer DiseaseAmyloid beta-PeptidesEntorhinal CortexFemaleHippocampusHumansMagnetic Resonance ImagingMaleNeuropsychological TestsPositron-Emission TomographyRepetition PrimingTauopathiestau ProteinsAmyloid beta-PeptidesMAPT protein, humantau ProteinsagingAlzheimer's diseasefMRIPETrepetition suppressiontau

Identifiers

PMID33731446
PMCPMC8084317
OpenAlexW3137352146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.