Evidence map›Paper›PMID 33731431›Full record

ArticleScience translational medicine2021

RNA-seq of human T cells after hematopoietic stem cell transplantation identifies

Daniel Peltier, Molly Radosevich, Visweswaran Ravikumar, Sethuramasundaram Pitchiaya, Thomas Decoville, Sherri C Wood, Guoqing Hou, Cynthia Zajac, Katherine Oravecz-Wilson, David Sokol and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. LNCing RNA to immunity.Trends in immunology · 2022
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Daniel PeltierDivision of Hematology and Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6069-9894
Molly RadosevichDivision of Hematology and Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1703-4771
Visweswaran RavikumarDepartments of Computational Medicine and Bioinformatics, Biostatistics, Radiation Oncology, and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4670-3898
Sethuramasundaram PitchiayaMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-2529-5186
Thomas DecovilleDivision of Hematology and Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Sherri C WoodDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Guoqing HouDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.
Cynthia ZajacDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.ORCID 0000-0003-2983-4175
Katherine Oravecz-WilsonDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6075-8452
David SokolDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.
Israel HenigDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.
Julia WuDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6671-2217
Stephanie KimDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8397-1616
Austin TaylorDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.
Hideaki FujiwaraDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.
Yaping SunDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA.
Arvind RaoDepartments of Computational Medicine and Bioinformatics, Biostatistics, Radiation Oncology, and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Arul M ChinnaiyanDepartment of Pathology, Michigan Center for Translational Pathology, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9282-3415
Daniel R GoldsteinDepartment of Internal Medicine, Institute of Gerontology, and Department of Microbiology and Immunology, Program of Michigan Biology of Cardiovascular Aging, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6695-979X
Pavan ReddyDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109, USA. reddypr@umich.edu.ORCID 0000-0001-7264-8429
Michigan Medicine · USUniversity of Michigan · USHoward Hughes Medical Institute · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Training Program in Molecular HematologyT32HL007622 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG WON CHOI, Jordan A. Shavit · 1986 to 2026
$9.2M
Advancing Child Health Through Cellular and Molecular BiologyK12HD028820 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Donna M. Martin · 2002 to 2026
$9.2M
Mechanisms to augment primary immunity in agingR01AG028082 · NIA · YALE UNIVERSITY · PI DENG, JANE C · 2007 to 2023
$6.9M
Synthesizing Image-derived Heterogeneity with Genomic measurements for Assessing Disease Aggressiveness in Lower Grade GliomasR37CA214955 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KURTEK, SEBASTIAN, RAO, ARVIND · 2018 to 2024
$3.9M
Physician Scientist Training in Age-Related DiseasesT32AG062403 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MIN, LILLIAN CHIANG, MODY, LONA · 2020 to 2025
$2.7M
Novel mechanisms of age-enhanced vasculopathy after heart transplantationR01AI138347 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDSTEIN, DANIEL ROBERT · 2018 to 2022
$2.7M
Cellular and molecular mechanisms of target tissue resistance for mitigating GVHD severityR01CA203542 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REDDY, PAVAN · 2016 to 2020
$2.4M
NCATS NIH HHS UL1 TR002240NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA203542NCI NIH HHS R01 CA217156NCI NIH HHS R37 CA214955NHGRI NIH HHS T32 HG000040NHLBI NIH HHS L40 HL138824NHLBI NIH HHS R01 HL128046NHLBI NIH HHS T32 HL007622NIAID NIH HHS R01 AI138347NIA NIH HHS P30 AG024824NIA NIH HHS R01 AG028082NIA NIH HHS T32 AG062403NICHD NIH HHS K12 HD028820NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

Mechanisms governing allogeneic T cell responses after solid organ and allogeneic hematopoietic stem cell transplantation (HSCT) are incompletely understood. To identify lncRNAs that regulate human donor T cells after clinical HSCT, we performed RNA sequencing on T cells from healthy individuals and donor T cells from three different groups of HSCT recipients that differed in their degree of major histocompatibility complex (MHC) mismatch. We found that lncRNA differential expression was greatest in T cells after MHC-mismatched HSCT relative to T cells after either MHC-matched or autologous HSCT. Differential expression was validated in an independent patient cohort and in mixed lymphocyte reactions using ex vivo healthy human T cells. We identified

Indexed as

Hematopoietic Stem Cell TransplantationT-LymphocytesAnimalsGraft vs Host DiseaseHistocompatibilityHumansMiceRNA, Long NoncodingRNA-SeqTransplantation, HomologousRNA, Long Noncoding

Identifiers

PMID33731431
PMCPMC8589011
OpenAlexW3136545858

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.