Evidence map›Paper›PMID 33731362›Full record

ArticleMolecular cancer research : MCR2021

Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase.

Hongzhuang Peng, Joel Cassel, Daniel S McCracken, Jeremy W Prokop, Eleonora Sementino, Mitchell Cheung, Paul R Collop, Alexander Polo, Surbhi Joshi, Jacob P Mandell and 9 more

Abstract read
In one paragraph

Article in Molecular cancer research : MCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Phenotype-Specific Recalibration of MAVE Data Enables Repurposing ofmedRxiv : the preprint server for health sciences · 2026
    Article
  2. BAP1 Loss Affords Lipotoxicity Resistance in Uveal Melanoma.Pigment cell & melanoma research · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Hongzhuang PengThe Wistar Institute, Philadelphia, Pennsylvania. joseph.testa@fccc.edu hongzhuangpeng851@gmail.com.
Joel CasselThe Wistar Institute, Philadelphia, Pennsylvania.
Daniel S McCrackenThe Wistar Institute, Philadelphia, Pennsylvania.
Jeremy W ProkopDepartment of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan.
Eleonora SementinoFox Chase Cancer Center, Philadelphia, Pennsylvania.
Mitchell CheungFox Chase Cancer Center, Philadelphia, Pennsylvania.
Paul R CollopDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia.
Alexander PoloThe Wistar Institute, Philadelphia, Pennsylvania.
Surbhi JoshiThe Wistar Institute, Philadelphia, Pennsylvania.
Jacob P MandellThe Wistar Institute, Philadelphia, Pennsylvania.
Kasirajan AyyanathanThe Wistar Institute, Philadelphia, Pennsylvania.
David HindsDepartment of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan.
S Bruce MalkowiczDepartment of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
J William HarbourUniversity of Miami School of Medicine, Miami, Florida.ORCID 0000-0002-1104-9809
Anne M BowcockIcahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0001-8691-9090
Joseph SalvinoThe Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0002-2184-5980
Eileen J KennedyDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia.ORCID 0000-0001-5610-1677
Joseph R TestaFox Chase Cancer Center, Philadelphia, Pennsylvania. joseph.testa@fccc.edu hongzhuangpeng851@gmail.com.ORCID 0000-0003-1301-5175
Frank J RauscherThe Wistar Institute, Philadelphia, Pennsylvania.

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Pathogenesis of Malignant Mesothelioma by the Human Polycomb Complex BAP1-ASXLR01CA175691 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI RAUSCHER III, FRANK JOSEPH, TESTA, JOSEPH R. · 2014 to 2018
$2.7M
Functional Analysis of the BAP1 Metastasis Suppressor Gene in Uveal MelanomaR01CA163761 · NCI · WISTAR INSTITUTE · PI RAUSCHER III, FRANK JOSEPH · 2012 to 2016
$1.8M
Probing the role of AKAPs in breast cancer using stapled peptide inhibitorsK22CA154600 · NCI · UNIVERSITY OF GEORGIA · PI KENNEDY, EILEEN J · 2011 to 2013
$571k
Using a Sequence-to-Structure-to-Function Approach to Functionally Characterize Protein Coding Missense Mutations in the Human and Rat GenomesK01ES025435 · NIEHS · MICHIGAN STATE UNIVERSITY · PI PROKOP, JEREMY WILLIAM · 2014 to 2018
$489k
NCI NIH HHS K22 CA154600NCI NIH HHS P30 CA006927NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA163761NCI NIH HHS R01 CA175691NIEHS NIH HHS K01 ES025435
6 · The paper itself

Abstract

BAP1 is an ubiquitin hydrolase whose deubiquitinase activity is mediated by polycomb group-like protein ASXL2. Cancer-related

Indexed as

Allosteric RegulationAmino Acid SequenceAnimalsBinding SitesHEK293 CellsHumansKineticsModels, MolecularProtein BindingProtein DomainsRepressor ProteinsSequence Homology, Amino AcidSf9 CellsSpodopteraTumor Suppressor ProteinsUbiquitinASXL1 protein, humanASXL2 protein, humanBAP1 protein, humanRepressor ProteinsTumor Suppressor ProteinsUbiquitinUbiquitin Thiolesterase

Identifiers

PMID33731362
PMCPMC8254751

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.