Evidence map›Paper›PMID 33731315›Full record

ArticleNeuroscience2021

Differential Behavioral and Neural Effects of Regional Cerebellar tDCS.

Laura C Rice, Anila M D'Mello, Catherine J Stoodley

Open access · greenAbstract read
In one paragraph

Article in Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Article
  7. Cerebellar tDCS Modulates Corticocortical Functional Networks in a Regionally Specific Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  8. Article
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  12. Cerebellar Neuromodulation Impacts Reading Fluency in Young Adults.Neurobiology of language (Cambridge, Mass.) · 2024
    Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laura C RiceDepartment of Neuroscience and Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave NW, Washington, DC 20016, USA. Electronic address: laura.blevins@student.american.edu.
Anila M D'MelloDepartment of Neuroscience and Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave NW, Washington, DC 20016, USA. Electronic address: admello@mit.edu.
Catherine J StoodleyDepartment of Neuroscience and Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave NW, Washington, DC 20016, USA. Electronic address: stoodley@american.edu.
American University · US

Funding

Cerebellar tDCS: A Novel Treatment for AphasiaR21DC014087 · NIDCD · GEORGETOWN UNIVERSITY · PI STOODLEY, CATHERINE J., TURKELTAUB, PETER ETHAN · 2016 to 2017
$448k
Cerebellum and autism: Neural mechanisms and modulation of predictive processingR15MH106957 · NIMH · AMERICAN UNIVERSITY · PI STOODLEY, CATHERINE J. · 2015 to 2015
$403k
NIDCD NIH HHS R21 DC014087NIMH NIH HHS R15 MH106957
6 · The paper itself

Abstract

The human cerebellum contributes to both motor and non-motor processes. Within the cerebellum, different subregions support sensorimotor and broader cognitive functions, due to regional patterns in anatomical connectivity with the cerebral cortex and spinal and vestibular systems. We evaluated the effects of transcranial direct current stimulation (tDCS) targeting different cerebellar regions on language task performance and whole-brain functional activation patterns. Functional MRI data were acquired while 43 healthy young adults (15 males, 28 females; 23.3 ± 3.0 years) performed a sentence completion task before and after 20 min of 1.5 mA anodal tDCS. Participants received tDCS targeting either the anterior sensorimotor cerebellum (n = 11; 3 cm right of inion, over lobule V); the right posterolateral cerebellum (n = 18; 1 cm down and 4 cm right of inion, over lobule VII); or sham tDCS (n = 14). TDCS targeting the right posterolateral cerebellum improved task accuracy relative to the sham condition (p = 0.04) and increased activation in left frontal and temporal cortices relevant to task performance (post-tDCS > pre-tDCS; T 3.17, FDR p < 0.05 cluster correction). The regions of increased BOLD signal after right posterolateral cerebellar tDCS fell within the network showing functional connectivity with right cerebellar lobule VII, suggesting specific modulation of this network. In contrast, tDCS targeting the sensorimotor cerebellum did not impact task performance and increased BOLD signal only in one cluster extending into the precentral gyrus. These findings indicate that sensorimotor and cognitive functional cerebellar subregions differentially impact behavioral task performance and task-relevant activation patterns, further contributing to our understanding of the cerebellar modulation of motor and non-motor functions.

Indexed as

Transcranial Direct Current StimulationBrainCerebellumCognitionFemaleHumansMagnetic Resonance ImagingMaleYoung Adultcerebellumcognitionfunctional MRIlanguagemotorneuromodulation

Identifiers

PMID33731315
PMCPMC8439007
OpenAlexW3137848906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.