ArticleHealth and quality of life outcomes2021
The path linking disease severity and cognitive function with quality of life in Parkinson's disease: the mediating effect of activities of daily living and depression.
Article in Health and quality of life outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Influence of Age on the Effectiveness of Lee Silverman Voice TreatmentGeriatrics (Basel, Switzerland) · 2026Article
- Combined Effects of Depression, Fatigue and Cardiovascular Dysfunction on Functional Dependence Over Seven Years in Early Parkinson's Disease.Movement disorders clinical practice · 2026Article
- New Challenges in the Study of Cognitive Impairment in Parkinson's Disease.Brain sciences · 2025Article
- Association between Physical Activity, Depression Severity and Parkinson's Symptoms in Older Adults with Parkinson's disease: A Cross-Sectional Study.Annals of geriatric medicine and research · 2025Article
- Predicting Cognitive Decline in Parkinson's Disease Using Artificial Neural Networks: An Explainable AI Approach.Brain sciences · 2025Article
- Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- Association between cognitive functioning and health-related quality of life and its mediation by depressive symptoms in older patients with kidney failure.Journal of nephrology · 2024Observational
- Association between Religiousness and Quality of Life among Patients in Brazil diagnosed with Idiopathic Parkinson's Disease.Journal of religion and health · 2024Article
- Depression is associated with the nonmotor symptoms of Parkinson's disease: A comparative analysis.Health science reports · 2024Article
- Effects of Rehabilitation Training on Cognitive Function in Parkinson's Disease with Subjective Cognitive Decline.Neuropsychiatric disease and treatment · 2024Article
- The pathobiological basis of depression in Parkinson disease: challenges and outlooks.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Review
- Effects of Multimodal Rehabilitation on the Activities of Daily Living, Quality of Life, and Burden of Care for Patients with Parkinson's Disease: A Randomized Control Study.Healthcare (Basel, Switzerland) · 2022Article
- Associations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson's disease.Scientific reports · 2022Article
- Impact of Gastrointestinal Symptoms on Health-Related Quality of Life in an Australian Parkinson's Disease Cohort.Parkinson's disease · 2022Article
- Circulating CircRNAs Panel Acts as a Biomarker for the Early Diagnosis and Severity of Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundResearch on quality of life (QOL) with Parkinson's disease (PD) has examined direct influencing factors, not mediators. The study aim was to explore whether PD severity and poor cognitive function may decrease physical and mental QOL by reducing activities of daily living (ADL) and increasing depression in sequence.
methodsWe conducted a cross-sectional questionnaire study of 150 PD hospital patients in China. PD severity, cognitive function, ADL, depression, and QOL were evaluated. We used structural equation modeling to analyze the mediating effects of ADL and depression on the association between PD severity/cognition and the physical health and mental health component summary scores measured by the SF36 quality of life instrument.
resultsThere was a significant mediating effect of PD severity on physical health via ADL and depression (95% CI: - 0.669, - 0.026), and a significant direct effect (p < 0.001). The mediating effect of PD severity on mental health via ADL and depression was significant (95% CI: - 2.135, - 0.726), but there was no direct effect (p = 0.548). There was a significant mediating effect of cognitive function on physical health via ADL and depression (95% CI: 0.025, 0.219) and a significant direct effect (p < 0.001). The mediating effect of cognitive function on mental health via ADL and depression was significant (95% CI: 0.256, 0.645), but there was no direct effect (p = 0.313). The physical health models showed a partial mediation, and the mental health models showed a complete mediation, of ADL and depression.
conclusionsPD severity and cognitive function increase depression by reducing ADL, leading to lower QOL, and directly or indirectly affect physical health and mental health through different pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.