Evidence map›Paper›PMID 33731033›Full record

ArticleBMC neurology2021

Relationship between electrode position of deep brain stimulation and motor symptoms of Parkinson's disease.

Feng Zhang, Feng Wang, Weiguo Li, Ning Wang, Chunlei Han, Shiying Fan, Peng Li, Lifeng Xu, Jianguo Zhang, Fangang Meng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  9. Subthalamic nucleus-language network connectivity predicts dopaminergic modulation of speech function in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Long-term safety and efficacy of frameless subthalamic deep brain stimulation in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Feng ZhangBeijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China.
Feng WangDepartments of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, 310000, Hangzhou, China.
Weiguo LiDepartment of neurosurgery, QiLu Hospital of Shandong University, Jinan, 250012, China.
Ning WangBeijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China.
Chunlei HanBeijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China.
Shiying FanBeijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China.
Peng LiDepartment of neurosurgery, the First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China.
Lifeng XuDepartment of neurosurgery, the First Hospital of Hebei Medical University, Shijiazhuang, 050031, Hebei, China.
Jianguo ZhangBeijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China. zjguo73@126.com.
Fangang MengBeijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China. fgmeng@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-4030-7811
Capital Medical University · CNHebei Medical University · CNFirst Affiliated Hospital Zhejiang University · CNQilu Hospital of Shandong University · CN

Funding

Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support XMLX201833, ZYLX201820National Natural Science Foundation of China 81971070Natural Science Foundation of Ningxia Province 2018BFG02007
6 · The paper itself

Abstract

backgroundTo investigate the relationship between the position of bilateral STN-DBS location of active contacts and the clinical efficacy of STN-DBS on motor symptoms in Parkinson's disease (PD) patients.

methodsRetrospectively analyze the clinical data of 57 patients with PD who underwent bilateral STN-DBS from March 2018 to December 2018. Unified Parkinson's Disease Rating Scale-Part III (UPDRS-III) score, levodopa equivalent day dose (LEDD), Parkinson's Disease Quality of Life Scale (PDQ-39) before operation and within 6 months after operation, determine the location of activated contacts and volume of tissue activated (VTA) in the Montreal Neurological Institute (MNI) space, and analyze their correlation with the improvement rate of motor symptoms (UPDRS-III score improvement rate).

resultsAfter 6 months of follow up, the UPDRS-III scores of 57 patients (Med-off) were improved by 55.4 ± 18.9% (P<0.001) compared with that before operation. The improvement rate of PDQ-39 scores [(47.4 ± 23.2)%, (P < 0.001)] and the reduction rate of LEDD [(40.1 ± 24.3)%, (P < 0.01)] at 6 months postoperation were positively correlated with the improvement rate of motor symptoms (Med-off)(PDQ-39:r = 0.461, P<0.001; LEDD: r = 0.354, P = 0.007), the improvement rate of UPDRS-III (Med-off) and the Z-axis coordinate of the active contact in the MNI space were positively correlated (left side: r = 0.349,P = 0.008;right side: r = 0.369,P = 0.005). In the MNI space, there was no correlation between the UPDRS-III scores improvement rate (Med-off) at 6 months after operation and bilateral VTA in the STN motor subregion, STN associative subregion and STN limbic subregion of the active electrode contacts of 57 patients (all P > 0.05). At 6 months after surgery, the difference between the Z-axis coordinate in the different improvement rate subgroups(<25, 25 to 50%, and>50%) in the MNI space was statistically significant (left side: P = 0.030; right side: P = 0.024). In the MNI space, there was no statistically significant difference between the groups in the VTA of the electrode active contacts (all P > 0.05).

conclusionSTN-DBS can improve the motor symptoms of PD patients and improve the quality of life. The closer the stimulation is to the STN dorsolateral sensorimotor area, the higher the DBS is to improve the motor symptoms of PD patients.

Indexed as

Quality of LifeAgedAged, 80 and overDeep Brain StimulationElectrodesFemaleHumansLevodopaMaleMental Status and Dementia TestsMiddle AgedParkinson DiseaseRetrospective StudiesSubthalamic NucleusTreatment OutcomeLevodopaActive contactsDeep brain stimulationMotor symptomParkinson’s diseaseSubthalamic nucleusVolume of tissue activated

Identifiers

PMID33731033
PMCPMC7972210
OpenAlexW3136300599

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.