Evidence map›Paper›PMID 33730778›Full record

ArticleAcute and critical care2021

Continuous heart rate variability and electroencephalography monitoring in severe acute brain injury: a preliminary study.

Hyunjo Lee, Sang-Beom Jeon, Kwang-Soo Lee

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acute and critical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07771101 (Association Between Early Autonomic Dysfunction Measured by the Analgesia Nociception Index), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07771101 recruitingnot on this mapstarted 2026, after this paper: background citation

Association Between Early Autonomic Dysfunction Measured by the Analgesia Nociception Index (ANI) and Prolonged Mechanical Ventilation in Postoperative ICU Patients

Typeobservational_patient_registrySponsorSeoul National University HospitalRan2026 to 2027Enrolled50ConditionsVentilator Weaning, Airway Extubation, Respiration, Artificial
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hyunjo LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sang-Beom JeonDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Kwang-Soo LeeDepartment of Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ulsan College · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KR

Funding

Korea Health Industry Development InstituteMinistry of Health and Welfare HI18C1487Ministry of Health and Welfare HI18C2383
6 · The paper itself

Abstract

backgroundDecreases in heart rate variability have been shown to be associated with poor outcomes in severe acute brain injury. However, it is unknown whether the changes in heart rate variability precede neurological deterioration in such patients. We explored the changes in heart rate variability measured by electrocardiography in patients who had neurological deterioration following severe acute brain injury, and examined the relationship between heart rate variability and electroencephalography parameters.

methodsRetrospective analysis of 25 patients who manifested neurological deterioration after severe acute brain injury and underwent simultaneous electroencephalography plus electrocardiography monitoring.

resultsEighteen electroencephalography channels and one simultaneously recorded electrocardiography channel were segmented into epochs of 120-second duration and processed to compute 10 heart rate variability parameters and three quantitative electroencephalography parameters. Raw electroencephalography of the epochs was also assessed by standardized visual interpretation and categorized based on their background abnormalities and ictalinterictal continuum patterns. The heart rate variability and electroencephalography parameters showed consistent changes in the 2-day period before neurological deterioration commenced. Remarkably, the suppression ratio and background abnormality of the electroencephalography parameters had significant reverse correlations with all heart rate variability parameters.

conclusionsWe observed a significantly progressive decline in heart rate variability from the day before the neurological deterioration events in patients with severe acute brain injury were first observed.

Indexed as

brain injuriescritical careelectrocardiographyelectroencephalography

Identifiers

PMID33730778
PMCPMC8182164
OpenAlexW3138410342

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.