Evidence map›Paper›PMID 33730747›Full record

ArticleAIDS (London, England)2021

Clinic and care: associations with adolescent antiretroviral therapy adherence in a prospective cohort in South Africa.

Lucie Cluver, Yulia Shenderovich, Elona Toska, William E Rudgard, Siyanai Zhou, Mark Orkin, Roxanna Haghighat, Angelique N Chetty, Caroline Kuo, Alice Armstrong and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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  14. The effect of substance uses on antiretroviral treatment adherence in primary health care.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Lucie CluverCentre for Evidence-Based Intervention, Department of Social Policy and Intervention, University of Oxford, Oxford, UK.
Yulia ShenderovichCentre for Evidence-Based Intervention, Department of Social Policy and Intervention, University of Oxford, Oxford, UK.
Elona ToskaCentre for Evidence-Based Intervention, Department of Social Policy and Intervention, University of Oxford, Oxford, UK.
William E RudgardCentre for Evidence-Based Intervention, Department of Social Policy and Intervention, University of Oxford, Oxford, UK.
Siyanai ZhouCentre for Social Science Research.
Mark OrkinCentre for Evidence-Based Intervention, Department of Social Policy and Intervention, University of Oxford, Oxford, UK.
Roxanna HaghighatCentre for Evidence-Based Intervention, Department of Social Policy and Intervention, University of Oxford, Oxford, UK.
Angelique N ChettyCentre for Evidence-Based Intervention, Department of Social Policy and Intervention, University of Oxford, Oxford, UK.
Caroline KuoSchool of Public Health, Brown University, Providence, Rhode Island, USA.
Alice ArmstrongUNICEF Eastern and Southern Africa Regional Office, Nairobi, Kenya.
Lorraine SherrHealth Psychology Unit, Institute of Global Health, University College London, London, UK.
University of Oxford · GBOxford Policy Management · GBBrown University · USUniversity College London · GBUniversity of Cape Town · ZA

Funding

Undetectable and Untransmittable: reducing HIV transmission among young women living with HIV, their partners and children in South AfricaK43TW011434 · FIC · UNIVERSITY OF CAPE TOWN · PI TOSKA, ELONA · 2019 to 2023
$720k
FIC NIH HHS K43 TW011434Medical Research Council MR/R022372/1
6 · The paper itself

Abstract

objectiveAdolescent antiretroviral treatment (ART) adherence remains critically low. We lack research testing protective factors across both clinic and care environments.

designA prospective cohort of adolescents living with HIV (sample n = 969, 55% girls, baseline mean age 13.6) in the Eastern Cape Province in South Africa were interviewed at baseline and 18-month follow-up (2014-2015, 2015-2016). We traced all adolescents ever initiated on treatment in 52 government health facilities (90% uptake, 93% 18-month retention, 1.2% mortality).

methodsClinical records were collected; standardized questionnaires were administered by trained data collectors in adolescents' language of choice. Probit within-between regressions and average adjusted probability calculations were used to examine associations of caregiving and clinic factors with adherence, controlling for household structure, socioeconomic and HIV factors.

resultsPast-week ART adherence was 66% (baseline), 65% (follow-up), validated against viral load in subsample. Within-individual changes in three factors were associated with improved adherence: no physical and emotional violence (12.1 percentage points increase in adjusted probability of adherence, P < 0.001), improvement in perceived healthcare confidentiality (7.1 percentage points, P < 0.04) and shorter travel time to the clinic (13.7 percentage points, P < 0.02). In combination, improvement in violence prevention, travel time and confidentiality were associated with 81% probability of ART adherence, compared with 47% with a worsening in all three.

conclusionAdolescents living with HIV need to be safe at home and feel safe from stigma in an accessible clinic. This will require active collaboration between health and child protection systems, and utilization of effective violence prevention interventions.

Indexed as

Anti-HIV AgentsHIV InfectionsAdolescentAnti-Retroviral AgentsChildFemaleHumansMaleMedication AdherenceProspective StudiesSouth AfricaViral LoadAnti-HIV AgentsAnti-Retroviral Agents

Identifiers

PMID33730747
PMCPMC8183481
OpenAlexW3138848248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.