ArticleCell reports2021
Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Sex and base excision repair as key susceptibility factors for alkylation-induced mutations, toxicity and hepatic cancer.DNA repair · 2026Article
- DNA adduct and mutational profiles reveal a threshold of cellular defenses againstNAR molecular medicine · 2026Article
- Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer.NAR cancer · 2026Article
- Early life exposure to N-nitrosamine drives genotoxicity, mutagenesis, and tumorigenesis in DNA repair-deficient mice.Nature communications · 2026Article
- Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer.bioRxiv : the preprint server for biology · 2025Article
- LC-ESI-HRMS-Based Evaluation of Antioxidants as Additives to Inhibit Genotoxic Nitrosamine Formation in Metformin Hydrochloride Tablets.AAPS PharmSciTech · 2025Article
- Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer.bioRxiv : the preprint server for biology · 2025Article
- The α-globin super-enhancer acts in an orientation-dependent manner.Nature communications · 2025Article
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing.Archives of toxicology · 2024Article
- Nitrosamines crisis in pharmaceuticals - Insights on toxicological implications, root causes and risk assessment: A systematic review.Journal of pharmaceutical analysis · 2024Review
- Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase.National science review · 2023Article
- Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome.Cell discovery · 2023Article
- Article
- Interaction ofDalton transactions (Cambridge, England : 2003) · 2023Article
- DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways.International journal of molecular sciences · 2023Review
- Transgenic mice harboring direct repeat substrates reveal key underlying causes of homologous recombination in vivo.DNA repair · 2022Review
- Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Multiple Mouse Tissues.International journal of molecular sciences · 2022Article
- AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations.Environmental and molecular mutagenesis · 2022Article
- Implications of an epidemiological study showing an association between in utero NDMA exposure and childhood cancer.Environmental and molecular mutagenesis · 2021Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Jennifer E KayDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Joshua J CorriganDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Amanda L ArmijoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Ilana S NazariDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Ishwar N KohaleDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Dorothea K TorousLitron Laboratories, Rochester, NY 14623, USA.
Svetlana L AvlasevichLitron Laboratories, Rochester, NY 14623, USA.
Robert G CroyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Dushan N WadduwageThe John Harvard Distinguished Science Fellows Program, Harvard University, Cambridge, MA 02138, USA; Center for Advanced Imaging, Harvard University, Cambridge, MA 02138, USA.
Sebastian E CarrascoDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Stephen D DertingerLitron Laboratories, Rochester, NY 14623, USA.
Forest M WhiteDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
John M EssigmannDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Leona D SamsonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 01239, USA.
Bevin P EngelwardDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 01239, USA. Electronic address: bevin@mit.edu.
Center for Environmental Health · USLitron Laboratories (United States) · USMassachusetts Institute of Technology · USHarvard University · US
Funding
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6MThe MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous ChemicalsP42ES027707 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Desiree Plata · 2017 to 2026
$22.2MTRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1MWide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3MIntra and Extra-Chromosomal Probes for Mutagenesis by CarcinogensR01CA080024 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1998 to 2025
$5.9MValidation of Cross-Species Biomarkers of DNA DamageR44ES028163 · NIEHS · LITRON LABORATORIES, LTD. · PI BEMIS, JEFFREY C, DERTINGER, STEPHEN D · 2018 to 2019
$1.4MAutomation of a Liver Genotoxicity AssayR44ES026464 · NIEHS · LITRON LABORATORIES, LTD. · PI BEMIS, JEFFREY C, DERTINGER, STEPHEN D · 2016 to 2018
$1.1MDevelopment of high-throughput cardiotoxicity and hepatotoxicity assays with magnetic 3D bioprintingR44ES024644 · NIEHS · NANO3D BIOSCIENCES, INC. · PI TSENG, HUBERT · 2017 to 2018
$1000kNCI NIH HHS R01 CA080024NIBIB NIH HHS P41 EB015871NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P42 ES027707NIEHS NIH HHS R44 ES024644NIEHS NIH HHS R44 ES026464NIEHS NIH HHS R44 ES028163NIEHS NIH HHS T32 ES007020
Abstract
N-Nitrosodimethylamine (NDMA) is a DNA-methylating agent that has been discovered to contaminate water, food, and drugs. The alkyladenine DNA glycosylase (AAG) removes methylated bases to initiate the base excision repair (BER) pathway. To understand how gene-environment interactions impact disease susceptibility, we study Aag-knockout (Aag
Indexed as
AnimalsBiomarkers, TumorCell DeathChromosomal InstabilityDiethylnitrosamineDisease SusceptibilityDNA DamageDNA GlycosylasesDNA RepairDNA ReplicationHistonesHomologous RecombinationLiverLiver NeoplasmsMiceMice, Inbred C57BL3-methyladenine-DNA glycosylaseBiomarkers, TumorDiethylnitrosamineDNA Glycosylasesgamma-H2AX protein, mouseHistonesNitrosaminesPhosphoproteinsalkyladenine DNA glycosylasecancerDNA damageDNA strand breaklivermutationnitrosaminereplication-blocking lesion
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.