Evidence map›Paper›PMID 33730578›Full record

ArticleCell reports2021

Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.

Xin Zhang, Xiaowen Wang, Ziqiang Yuan, Sarah J Radford, Chen Liu, Steven K Libutti, X F Steven Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xin ZhangRutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA.
Xiaowen WangRutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA.
Ziqiang YuanRutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Surgery, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA.
Sarah J RadfordRutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA.
Chen LiuDepartment of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA.
Steven K LibuttiRutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Surgery, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA.
X F Steven ZhengRutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08901, USA; Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA. Electronic address: zhengst@cinj.rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
Oncogenic Chromatin Remodeling and Anticancer MechanismsR01CA280177 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI STEVEN ZHENG · 2023 to 2026
$1.8M
Role of Rab1 in Cell Growth and CancerR01CA173519 · NCI · RBHS -CANCER INSTITUTE OF NEW JERSEY · PI ZHENG, STEVEN · 2013 to 2017
$1.6M
Amino Acids-Rab1A Nutrient Signaling in the Regulation of Glucose HomeostasisR01DK124897 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ZHENG, STEVEN · 2020 to 2023
$1.5M
NCI NIH HHS P30 CA072720NCI NIH HHS R01 CA173519NCI NIH HHS R01 CA280177NIDDK NIH HHS R01 DK124897
6 · The paper itself

Abstract

Rab1A is a small GTPase known for its role in vesicular trafficking. Recent evidence indicates that Rab1A is essential for amino acids (aas) sensing and signaling to regulate mTORC1 in normal and cancer cells. However, Rab1A's in vivo function in mammals is not known. Here, we report the generation of tamoxifen (TAM)-induced whole body Rab1A knockout (Rab1A

Indexed as

HomeostasisSignal TransductionAmino AcidsAnimalsCell NucleusDiabetes Mellitus, Type 2Down-RegulationGlucoseGlucose IntoleranceHomeodomain ProteinsHyperglycemiaInsulinInsulin SecretionIslets of LangerhansMechanistic Target of Rapamycin Complex 1MiceAmino AcidsGlucoseHomeodomain ProteinsInsulinMechanistic Target of Rapamycin Complex 1pancreatic and duodenal homeobox 1 proteinrab1 GTP-Binding ProteinsTrans-Activatorsalpha-cellamino acidsbeta-celldiabetesglucose homeostasisinsulinmTORPDX1Rab1Atrans-differentiation

Identifiers

PMID33730578
PMCPMC8062038
OpenAlexW3137424779

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.