Evidence map›Paper›PMID 33730571›Full record

ArticleCell reports2021

Transcriptome-wide association study reveals two genes that influence mismatch negativity.

Anjali Bhat, Haritz Irizar, Johan Hilge Thygesen, Karoline Kuchenbaecker, Oliver Pain, Rick A Adams, Eirini Zartaloudi, Jasmine Harju-Seppänen, Isabelle Austin-Zimmerman, Baihan Wang and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  3. Neighborhood social fragmentation in relation to impaired mismatch negativity among youth at clinical high risk for psychosis and healthy comparisons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Anjali BhatDivision of Psychiatry, University College London, London, UK; Wellcome Centre for Human Neuroimaging, University College London, London, UK; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK. Electronic address: anjali.bhat.14@ucl.ac.uk.
Haritz IrizarDivision of Psychiatry, University College London, London, UK.
Johan Hilge ThygesenDivision of Psychiatry, University College London, London, UK.
Karoline KuchenbaeckerDivision of Psychiatry, University College London, London, UK; UCL Genetics Institute, University College London, London, UK.
Oliver PainSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Rick A AdamsDivision of Psychiatry, University College London, London, UK; Institute of Cognitive Neuroscience, University College London, London, UK.
Eirini ZartaloudiDivision of Psychiatry, University College London, London, UK.
Jasmine Harju-SeppänenDivision of Psychiatry, University College London, London, UK; Department of Clinical, Educational and Health Psychology, University College London, London, UK.
Isabelle Austin-ZimmermanDivision of Psychiatry, University College London, London, UK.
Baihan WangDivision of Psychiatry, University College London, London, UK.
Rebecca MuirDivision of Psychiatry, University College London, London, UK.
Ann SummerfeltMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD, USA.
Xiaoming Michael DuMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD, USA.
Heather BruceMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD, USA.
Patricio O'DonnellMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Takeda Pharmaceuticals, Cambridge, MA, USA.
Deepak P SrivastavaInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.
Karl FristonWellcome Centre for Human Neuroimaging, University College London, London, UK.
L Elliot HongMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD, USA.
Mei-Hua HallDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; Psychosis Neurobiology Laboratory, McLean Hospital, Belmont, MA, USA.
Elvira BramonDivision of Psychiatry, University College London, London, UK; Institute of Cognitive Neuroscience, University College London, London, UK; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK; Camden and Islington NHS Foundation Trust, London, UK. Electronic address: e.bramon@ucl.ac.uk.
University College London · GBKing's College London · GBUniversity of Maryland, Baltimore · USHarvard University · USWellcome Centre for Human Neuroimaging · GB

Funding

Towards Multisystem-Brain Successful Aging in Schizophrenia SpectrumR01MH116948 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HONG, L ELLIOT ELLIOT · 2018 to 2022
$3.7M
Neurobiological Markers as Predictors of Later Functional Outcome in First Episode PsychosisR01MH109687 · NIMH · MCLEAN HOSPITAL · PI HALL, MEI-HUA · 2016 to 2021
$2.5M
The Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia SpectrumR01MH112180 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT · 2017 to 2021
$1.0M
Medical Research Council D79/543369/D-OTH/170890Medical Research Council G0901310Medical Research Council G1100583Medical Research Council MC_PC_16014Medical Research Council MR/L021064/1Medical Research Council MR/N026063/1Medical Research Council MR/S007806/1Medical Research Council MR/W006251/1NIMH NIH HHS R01 MH109687NIMH NIH HHS R01 MH112180NIMH NIH HHS R01 MH116948Wellcome TrustWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/Z
6 · The paper itself

Abstract

Mismatch negativity (MMN) is a differential electrophysiological response measuring cortical adaptability to unpredictable stimuli. MMN is consistently attenuated in patients with psychosis. However, the genetics of MMN are uncharted, limiting the validation of MMN as a psychosis endophenotype. Here, we perform a transcriptome-wide association study of 728 individuals, which reveals 2 genes (FAM89A and ENGASE) whose expression in cortical tissues is associated with MMN. Enrichment analyses of neurodevelopmental expression signatures show that genes associated with MMN tend to be overexpressed in the frontal cortex during prenatal development but are significantly downregulated in adulthood. Endophenotype ranking value calculations comparing MMN and three other candidate psychosis endophenotypes (lateral ventricular volume and two auditory-verbal learning measures) find MMN to be considerably superior. These results yield promising insights into sensory processing in the cortex and endorse the notion of MMN as a psychosis endophenotype.

Indexed as

Genome-Wide Association StudyAdolescentAdultAgedAged, 80 and overCerebral VentriclesChildElectrophysiological PhenomenaFemaleHumansIntracellular Signaling Peptides and ProteinsIntrinsically Disordered ProteinsMaleMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseMemory, Short-TermMiddle AgedFAM89A protein, humanIntracellular Signaling Peptides and ProteinsIntrinsically Disordered ProteinsMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseNeurotransmitter AgentsReceptors, VirusBayesian brainendophenotypegene expressionmismatch negativityMMNneurodevelopmentprediction errorpsychosisschizophreniatranscriptome-wide association study

Identifiers

PMID33730571
PMCPMC7972991
OpenAlexW3136028441

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.