ArticleJournal of biomechanics2021
Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.
Article in Journal of biomechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Marathon Running Transiently Causes Medial Meniscus Extrusion: Recovery Time Course and Factors Associated With Extrusion.Scandinavian journal of medicine & science in sports · 2026Article
- Assessing the micromechanical architecture of joint tissues with speckle rheological microscopy.Nature communications · 2026Article
- Biomechanics of horizontal meniscus tear and healing during knee flexion: Finite element analysis.Mechanobiology in medicine · 2025Article
- Hybrid Hydrogels Augmented via Additive Network Integration (HANI) for Meniscal Tissue Engineering Applications.Gels (Basel, Switzerland) · 2025Article
- A review of finite element modeling and surgical simulation of meniscal tear in knee joint: progress and challenges.Frontiers in medicine · 2025Review
- [Tissue biomechanics: connective tissue characterization : Cluster tissue biomechanics].Orthopadie (Heidelberg, Germany) · 2024Review
- Development of Improved Confined Compression Testing Setups for Use in Stress Relaxation Testing of Viscoelastic Biomaterials.Gels (Basel, Switzerland) · 2024Article
- Assessing the role of surface layer and molecular probe size in diffusion within meniscus tissue.PloS one · 2024Article
- Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus.Osteoarthritis and cartilage open · 2023Article
- Tensile energy dissipation and mechanical properties of the knee meniscus: relationship with fiber orientation, tissue layer, and water content.Frontiers in bioengineering and biotechnology · 2023Article
- Biomechanical properties of porcine meniscus as determined via AFM: Effect of region, compartment and anisotropy.PloS one · 2023Article
- Age influence on resistance and deformation of the human sutured meniscal horn in the immediate postoperative period.Frontiers in bioengineering and biotechnology · 2023Article
- Strain-Dependent Diffusivity of Small and Large Molecules in Meniscus.Journal of biomechanical engineering · 2022Article
- Effect of corneal collagen crosslinking on viscoelastic shear properties of the cornea.Journal of the mechanical behavior of biomedical materials · 2022Article
- Mechanisms of energy dissipation and relationship with tissue composition in human meniscus.Osteoarthritis and cartilage · 2022Article
- Mechanical properties of meniscal circumferential fibers using an inverse finite element analysis approach.Journal of the mechanical behavior of biomedical materials · 2022Article
- Evolution of Meniscal Biomechanical Properties with Growth: An Experimental and Numerical Study.Bioengineering (Basel, Switzerland) · 2021Article
- 3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The meniscus is crucial in maintaining the knee function and protecting the joint from secondary pathologies, including osteoarthritis. Although most of the mechanical properties of human menisci have been characterized, to our knowledge, its dynamic shear properties have never been reported. Moreover, little is known about meniscal shear properties in relation to tissue structure and composition. This is crucial to understand mechanisms of meniscal injury, as well as, in regenerative medicine, for the design and development of tissue engineered scaffolds mimicking the native tissue. Hence, the objective of this study was to characterize the dynamic and equilibrium shear properties of human meniscus in relation to its anisotropy and composition. Specimens were prepared from the axial and the circumferential anatomical planes of medial and lateral menisci. Frequency sweeps and stress relaxation tests yielded storage (G') and loss moduli (G″), and equilibrium shear modulus (G). Correlations of moduli with water, glycosaminoglycans (GAGs), and collagen content were investigated. The meniscus exhibited viscoelastic behavior. Dynamic shear properties were related to tissue composition: negative correlations were found between G', G″ and G, and meniscal water content; positive correlations were found for G' and G″ with GAG and collagen (only in circumferential samples). Circumferential samples, with collagen fibers orthogonal to the shear plane, exhibited superior dynamic mechanical properties, with G' ~70 kPa and G″ ~10 kPa, compared to those of the axial plane ~15 kPa and ~1 kPa, respectively. Fiber orientation did not affect the values of G, which ranged from ~50 to ~100 kPa.
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