ArticleAnnual review of neuroscience2021
Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration.
Article in Annual review of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How perceptual learning rewires brain connectivity: lessons from the visual system in a top-down perspective.Frontiers in neural circuits · 2025Pooled it
- A topographic protomap in mouse subplate neurons precedes the onset of sensory experience.Nature communications · 2026Article
- Altered Excitation-Inhibition Balance and mGluRInternational journal of molecular sciences · 2026Article
- Article
- Region- and Layer-Specific Glutamatergic Synapse Development in the Nascent Cortical Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.bioRxiv : the preprint server for biology · 2026Article
- Association learning drives synaptic plasticity at feedforward synapses in somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Review
- Concordant transcriptional and morphological remodeling revealed bybioRxiv : the preprint server for biology · 2026Article
- A novel framework for expanding RNNs with biophysical detail to solve cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- Subthreshold Kir and IBiological research · 2026Article
- Voltage imaging as a window into neural computation.Neurophotonics · 2026Article
- Presynaptic control of top-down signaling in neocortical layer 1.bioRxiv : the preprint server for biology · 2026Article
- Secondary Somatosensory Cortex Is Required for Learning but Not Execution of a Tactile Discrimination.The European journal of neuroscience · 2026Article
- Nested spatiotemporal theta-gamma waves organize hierarchical processing across the mouse visual cortex.Nature communications · 2026Article
- Article
- Learned adaptive properties for mitigation of weight perturbations in embedded spiking networks.Frontiers in neuroscience · 2026Article
- RHO GTPase by L1 GABAergic neurons in frontal cortex and L6 glutamatergic neurons in prefrontal cortex differentiates states of unconsciousness.Scientific reports · 2025Article
- Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics.bioRxiv : the preprint server for biology · 2025Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Many of our daily activities, such as riding a bike to work or reading a book in a noisy cafe, and highly skilled activities, such as a professional playing a tennis match or a violin concerto, depend upon the ability of the brain to quickly make moment-to-moment adjustments to our behavior in response to the results of our actions. Particularly, they depend upon the ability of the neocortex to integrate the information provided by the sensory organs (bottom-up information) with internally generated signals such as expectations or attentional signals (top-down information). This integration occurs in pyramidal cells (PCs) and their long apical dendrite, which branches extensively into a dendritic tuft in layer 1 (L1). The outermost layer of the neocortex, L1 is highly conserved across cortical areas and species. Importantly, L1 is the predominant input layer for top-down information, relayed by a rich, dense mesh of long-range projections that provide signals to the tuft branches of the PCs. Here, we discuss recent progress in our understanding of the composition of L1 and review evidence that L1 processing contributes to functions such as sensory perception, cross-modal integration, controlling states of consciousness, attention, and learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.