Evidence map›Paper›PMID 33730384›Full record

Trial reportAlcoholism, clinical and experimental research2021

A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy.

Corinne N Kacmarek, Brian T Yates, Charla Nich, Brian D Kiluk

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Alcoholism, clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Psychosocial Interventions for Alcohol Use Disorder: A Review of Efficacy, Mechanisms, and Clinical Implications.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Corinne N KacmarekDepartment of Psychology, American University, Washington, DC, USA.ORCID 0000-0003-4863-1891
Brian T YatesDepartment of Psychology, American University, Washington, DC, USA.
Charla NichDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Brian D KilukDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1175-7979
American University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Efficacy and Mechanisms of CBT4CBT for Alcohol Use DisordersR01AA024122 · NIAAA · YALE UNIVERSITY · PI KILUK, BRIAN D. · 2016 to 2020
$2.7M
Integrating Cognitive Neuroscience Toward Understanding of Mechanisms of CBT for Alcohol Use DisordersK02AA027300 · NIAAA · YALE UNIVERSITY · PI KILUK, BRIAN D. · 2019 to 2023
$719k
A Stage I Study of Computer Based Training in CBT for Alcohol Use DisordersR21AA021405 · NIAAA · YALE UNIVERSITY · PI CARROLL, KATHLEEN M. · 2012 to 2013
$358k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K02 AA027300NIAAA NIH HHS R01 AA024122NIAAA NIH HHS R21 AA021405
6 · The paper itself

Abstract

backgroundComputer-based delivery of cognitive behavioral therapy (CBT) may be a less costly approach to increase dissemination and implementation of evidence-based treatments for alcohol use disorder (AUD). However, comprehensive evaluations of costs, cost-effectiveness, and cost-benefit of computer-delivered interventions are rare.

methodsThis study used data from a completed randomized clinical trial to evaluate the cost-effectiveness and cost-benefit of a computer-based version of CBT (CBT4CBT) for AUD. Sixty-three participants were randomized to receive one of the following treatments at an outpatient treatment facility and attended at least one session: (1) treatment as usual (TAU), (2) CBT4CBT plus treatment as usual (CBT4CBT+TAU), or (3) CBT4CBT plus brief monitoring.

resultsMedian protocol treatment costs per participant differed significantly between conditions, Kruskal-Wallis H(2) = 8.40, p = 0.02, such that CBT4CBT+TAU and CBT4CBT+monitoring each cost significantly more per participant than TAU. However, when nonprotocol treatment costs were included, total treatment costs per participant did not differ significantly between conditions. Median incremental cost-effective ratios (ICERs) revealed that CBT4CBT+TAU was more costly and more effective than TAU. It cost $35.08 to add CBT4CBT to TAU to produce a reduction of one additional drinking day per month between baseline and the end of the 8-week treatment protocol: CBT4CBT+monitoring cost $33.70 less to produce a reduction of one additional drinking day per month because CBT4CBT+monitoring was less costly than TAU and more effective at treatment termination, though not significantly so. Net benefit analyses suggested that costs of treatment, regardless of condition, did not offset monthly costs related to healthcare utilization, criminal justice involvement, and employment disruption between baseline and 6-month follow-up. Benefit-cost ratios were similar for each condition.

conclusionsResults of this pilot economic evaluation suggest that an 8-week course of CBT4CBT may be a cost-effective addition and potential alternative to standard outpatient treatment for AUD. Additional research is needed to generate conclusions about the cost-benefit of providing CBT4CBT to treatment-seeking individuals participating in standard outpatient treatment.

Indexed as

AdultAlcoholismAmbulatory CareCognitive Behavioral TherapyCost-Benefit AnalysisFemaleHealth ServicesHumansMaleMiddle AgedPilot ProjectsTherapy, Computer-AssistedTreatment Outcomealcohol use disorderCBT4CBTcomputer-delivered treatmentcost-benefitcost-effectiveness

Identifiers

PMID33730384
PMCPMC8131237
OpenAlexW3138144957

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.