ArticleInternal and emergency medicine2022
Comparison of Troponin I levels versus myocardial dysfunction on prognosis in sepsis.
Article in Internal and emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis.Critical care (London, England) · 2025Pooled it
- Early time-weighted average PEEP and mortality in sepsis-associated myocardial injury requiring invasive mechanical ventilation: a retrospective cohort study with external validation.Frontiers in cellular and infection microbiology · 2026Article
- Cardiac Troponin I as a Prognostic Indicator of Mortality in Patients With Sepsis and Organ Dysfunction.Cureus · 2026Article
- From Fluid Responsiveness to Prognosis: The Emerging Role of Point-of-Care Echocardiography in Sepsis.Diagnostics (Basel, Switzerland) · 2025Review
- Identification of Prognostic Factors for Sepsis or Septic Shock Patients with Cardiac Dysfunction.Journal of cardiovascular translational research · 2025Article
- Impact of left ventricular stroke work index on 30-day mortality in sepsis: a retrospective analysis based on the MIMIC-III database.BMC infectious diseases · 2025Observational
- Septic Cardiomyopathy: Difficult Definition, Challenging Diagnosis, Unclear Treatment.Journal of clinical medicine · 2025Review
- Inflammatory mechanisms and intervention strategies for sepsis-induced myocardial dysfunction.Immunity, inflammation and disease · 2023Review
- Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction.Frontiers in endocrinology · 2023Article
- Septic cardiomyopathy: Diagnosis and management.Journal of intensive medicine · 2022Review
- Progress in the Clinical Assessment and Treatment of Myocardial Depression in Critically Ill Patient with Sepsis.Journal of inflammation research · 2022Review
- Speckle-tracking echocardiography for detecting myocardial dysfunction in sepsis and septic shock patients: A single emergency department study.World journal of emergency medicine · 2022Article
- The predictive value of left ventricular global longitudinal strain in normotensive critically ill septic patients.Critical care scienceObservational
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the context of sepsis, we tested the relationship between echocardiographic findings and Troponin, and their impact on prognosis. In this prospective study, we enrolled 325 septic patients (41% with shock), not mechanically ventilated, between October, 2012 and June, 2019 among those admitted to our High-Dependency Unit. By echocardiography within 24 h from the admission, sepsis-induced myocardial dysfunction (SIMD) was defined as left ventricular (LV) systolic dysfunction (speckle-tracking-based global longitudinal peak systolic strain, GLS, > - 14%) and/or right ventricular (RV) systolic dysfunction (Tricuspid Annular Plane Systolic Excursion, TAPSE < 16 mm). Troponin I levels were measured upon admission (T0) and after 24 h (T1); it was considered normal if > 0.1 ng/mL. Mortality was assessed at day-7 and day-28 end-points. One-hundred and forty-two patients had normal Troponin level at T0 and T1 (G1), 69 had abnormal levels at T0 or T1 (G2) and 114 showed abnormal Troponin levels at both T0 and T1 (G3). Compared to G1, patients in G3 had worse LV and RV systolic function (GLS - 11.6 ± 3.4% vs - 14.0 ± 3.5%, p < 0.001; TAPSE 18 ± 0.5 vs 19 ± 0.5 mm, p = 0.047) and greater day-28 (34% vs 20%, p = 0.015) mortality. In a Cox survival analysis including age, Troponin and SOFA score, mortality was predicted by the presence of SIMD (RR 3.24, 95% CI 1.72-6.11, p < 0.001) with no contribution of abnormal Troponin level. While abnormal Troponin levels were associated with SIMD diagnosed by echocardiography, only the presence of SIMD predicted the short- and medium-term mortality rate, without an independent contribution of increased Troponin levels.
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