Evidence map›Paper›PMID 33730354›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Non-modified RNA-Based Reprogramming of Human Dermal Fibroblasts into Induced Pluripotent Stem Cells.

Immacolata Belviso, Franca Di Meglio, Veronica Romano, Stefania Montagnani, Clotilde Castaldo

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Immacolata BelvisoDepartment of Public Health, University of Naples Federico II, Naples, Italy.
Franca Di MeglioDepartment of Public Health, University of Naples Federico II, Naples, Italy.
Veronica RomanoDepartment of Public Health, University of Naples Federico II, Naples, Italy.
Stefania MontagnaniDepartment of Public Health, University of Naples Federico II, Naples, Italy.
Clotilde CastaldoDepartment of Public Health, University of Naples Federico II, Naples, Italy. clotilde.castaldo@unina.it.
University of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The generation of pluripotent stem cells from adult somatic cells by cell reprogramming has put a whole new perspective on stem cell biology and stem cell-based regenerative medicine. Cell reprogramming acts through the introduction of key genes that regulate and maintain the pluripotent cell state. In this chapter, we describe the optimized protocol for the efficient isolation of fibroblasts from a skin punch biopsy and the subsequent easy and effective generation of integration-free induced pluripotent stem cell (iPSC) colonies forcing the expression of specific factors by non-modified RNAs.

Indexed as

Induced Pluripotent Stem CellsPluripotent Stem CellsAdultCell DifferentiationCellular ReprogrammingFibroblastsHumansRNARNACell ReprogrammingDermal FibroblastsInduced Pluripotent Stem Cells (iPSCs)Integration-freeNon-modified RNAs (NM-RNAs)Regenerative Medicine

Identifiers

PMID33730354
OpenAlexW3136425650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.