Evidence map›Paper›PMID 33730346›Full record

ArticleDigestive diseases and sciences2022

Efficacy of Contrast-Enhanced Harmonic Endoscopic Ultrasound for Pancreatic Solid Tumors with a Combination of Qualitative and Quantitative Analyses: A Prospective Pilot Study.

Yuhei Iwasa, Takuji Iwashita, Hironao Ichikawa, Naoki Mita, Shinya Uemura, Kensaku Yoshida, Keisuke Iwata, Tsuyoshi Mukai, Ichiro Yasuda, Masahito Shimizu

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuhei IwasaFirst Department of Internal Medicine, Gifu University Hospital, Gifu, Japan.
Takuji IwashitaFirst Department of Internal Medicine, Gifu University Hospital, Gifu, Japan. takuji@w7.dion.ne.jp.ORCID 0000-0003-4978-1787
Hironao IchikawaFirst Department of Internal Medicine, Gifu University Hospital, Gifu, Japan.
Naoki MitaFirst Department of Internal Medicine, Gifu University Hospital, Gifu, Japan.
Shinya UemuraFirst Department of Internal Medicine, Gifu University Hospital, Gifu, Japan.
Kensaku YoshidaDepartment of Gastroenterology, Gifu Prefectural General Medical Center, Gifu, Japan.
Keisuke IwataDepartment of Gastroenterology, Gifu Prefectural General Medical Center, Gifu, Japan.
Tsuyoshi MukaiDepartment of Gastroenterology, Gifu Municipal Hospital, Gifu, Japan.
Ichiro YasudaThird Department of Internal Medicine, University of Toyama Hospital, Toyama, Japan.
Masahito ShimizuFirst Department of Internal Medicine, Gifu University Hospital, Gifu, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionImage evaluation of contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) and additional time-intensity curve (TIC) analysis enable qualitative and quantitative analyses of pancreatic tumor based on real-time perfusion imaging.

aimsTo evaluate the efficacy of CEH-EUS with a combination of qualitative and quantitative analyses of pancreatic solid tumors.

methodsPatients were scheduled to undergo EUS-guided fine needle aspiration (FNA) for pancreatic solid tumors were prospectively enrolled between 11/2016 and 12/2018 and underwent CEH-EUS. The vascular and enhancement patterns were qualitatively evaluated and heterogeneous enhancement was defined to be indicative of malignancy. The echo intensity change during 60 s in the tumor was quantitatively evaluated by time intensity curve analysis.

resultsIn total, 100 patients were enrolled in this study. The final diagnoses were malignant lesions in 87 patients and benign legions in 13 patients. There were four categories of enhancement and patterns: hypovascular with heterogeneous, hypovascular with homogeneous, hypervascular heterogeneous, and hypervascular homogeneous enhancement. The diagnostic capability of qualitative analysis was the sensitivity, specificity, and accuracy of 89%, 62%, and 85%, respectively. With respect to time intensity curve analysis, the time to peak of malignant lesions was significantly shorter than those of benign lesions (P = 0.0009) with an optimal cutoff value of 12.81 s on the receiver operating characteristic curve analysis. With the combination of qualitative and quantitative analyses, the sensitivity, specificity, and accuracy were improved to 100%, 54%, and 94%, respectively.

conclusionsCEH-EUS with combined qualitative and quantitative analyses for pancreatic tumors might be useful as a complement for EUS-FNA. The UMIN Clinical Trials Registry (UMIN000025192).

Indexed as

Contrast MediaPancreatic NeoplasmsEndoscopic Ultrasound-Guided Fine Needle AspirationEndosonographyHumansPancreasPilot ProjectsProspective StudiesContrast MediaContrast enhancedFine needle biopsyImage enhancementMicrobubblePerfluorobutanePerfusion

Identifiers

PMID33730346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.