Evidence map›Paper›PMID 33730321›Full record

ArticleJournal of autism and developmental disorders2022

Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children.

Tomoko Horinouchi, Kaori Maeyama, Masashi Nagai, Masami Mizobuchi, Yasuko Takagi, Yuka Okada, Takeshi Kato, Mio Nishimura, Yoko Kawasaki, Mieko Yoshioka and 11 more

Abstract read
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In one paragraph

Article in Journal of autism and developmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 1 country.

Tomoko HorinouchiDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Kaori MaeyamaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Masashi NagaiDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Masami MizobuchiDepartment of Developmental Pediatrics, Shizuoka Children's Hospital, Shizuoka, Japan.
Yasuko TakagiGeneral Pediatric and Rehabilitation Center for the Disabled, Kobe, Japan.
Yuka OkadaEastern Pediatric and Rehabilitation Center for the Disabled, Kobe, Japan.
Takeshi KatoWestern Pediatric and Rehabilitation Center for the Disabled, Kobe, Japan.
Mio NishimuraNikoniko-House Medical Welfare Center, Kobe, Japan.
Yoko KawasakiNikoniko-House Medical Welfare Center, Kobe, Japan.
Mieko YoshiokaGeneral Pediatric and Rehabilitation Center for the Disabled, Kobe, Japan.
Satoshi TakadaGeneral Pediatric and Rehabilitation Center for the Disabled, Kobe, Japan.
Hisayuki MatsumotoDivision of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
Yuji NakamachiDivision of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
Jun SaegusaDivision of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
Sachiyo FukushimaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Kazumichi FujiokaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Kazumi TomiokaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiroaki NagaseDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Kandai NozuDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Kazumoto IijimaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Noriyuki NishimuraDepartment of Public Health, Kobe University Graduate School of Health Science, 7-10-2 Tomogaoka, Suma-ku, Kobe, 654-0142, Japan. nnishi@med.kobe-u.ac.jp.ORCID http://orcid.org/0000-0002-9000-4341
Kobe University · JPHiroshima Prefectural Rehabilitation Center · JPKobe University Hospital · JPNikon (Japan) · JPKobe Children's Hospital · JPNational Rehabilitation Center for Persons with Disabilities · JPShizuoka Children's Hospital · JP

Funding

Japan Society for the Promotion of Science 17K16299
6 · The paper itself

Abstract

Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G > A), and UGT1A1*27 (c.686 C > A). The allele frequency of UGT1A1*6 (OR = 1.34, p = 0.26) and UGT1A1*28 (OR = 0.80, p = 0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.

Indexed as

Autism Spectrum DisorderJaundice, NeonatalChildFemaleGlucuronosyltransferaseHumansInfant, NewbornPolymorphism, GeneticPregnancyRisk FactorsUGT1A1 EnzymeUmbilical CordGlucuronosyltransferaseUGT1A1 EnzymeAutism spectrum disorderDried umbilical cordNeonatal jaundicePolymorphismUGT1A1

Identifiers

PMID33730321
OpenAlexW3138908895

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.