Evidence map›Paper›PMID 33730212›Full record

SynthesisClinical oral investigations2021

The immunohistochemical profile of basal cell nevus syndrome-associated and sporadic odontogenic keratocysts: a systematic review and meta-analysis.

Eleni-Marina Kalogirou, Grigorios Thermos, Vasileios Zogopoulos, Spyros Foutadakis, Ioannis Michalopoulos, Marios Agelopoulos, Konstantinos I Tosios

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. What is Currently Known about Odontogenic Keratocysts?Oral health & preventive dentistry · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eleni-Marina KalogirouDepartment of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece. eleni_kalogirou@hotmail.com.ORCID http://orcid.org/0000-0001-7891-4804
Grigorios ThermosDepartment of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0000-0002-5339-8302
Vasileios ZogopoulosCenter of Systems Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece.ORCID http://orcid.org/0000-0002-4646-5570
Spyros FoutadakisCenter of Basic Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Ioannis MichalopoulosCenter of Systems Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece.ORCID http://orcid.org/0000-0001-8991-8712
Marios AgelopoulosCenter of Basic Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Konstantinos I TosiosDepartment of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0000-0002-8834-6078
National and Kapodistrian University of Athens · GRAcademy of Athens · GRBiomedical Research Foundation of the Academy of Athens · GR

Funding

State Scholarships Foundation (GR) MIS-5000432
6 · The paper itself

Abstract

objectivesTo provide a systematic review of the literature on studies comparing the immunoprofile of nevoid basal cell carcinoma syndrome (BCNS)-associated and sporadic odontogenic keratocysts (OKCs), in order to identify markers that could accurately distinguish the two OKC subtypes. MATERIALS AND

methodsWe searched MEDLINE/Pubmed, Web of Science, EMBASE via OVID, and grey literature for publications until December 28th, 2019, that compared the immunohistochemical expression of the two OKC subtypes. The studies were qualitatively assessed using the Critical Appraisal Tool for Case Series (Joana Briggs Institute). Sensitivity and specificity, positive and negative likelihood ratio, diagnostic odds ratio and area under the curve, and pooled estimates were calculated, using a random-effects model.

resultsSeventy-one studies were qualitatively analyzed; 61 markers were evaluated in one study and 32 in ≥ 2 studies. Twenty-five studies reported differential expression of 29 markers in the form of higher number of positive cells or greater staining intensity usually in BCNS-associated OKCs. Meta-analysis for bcl-2, Cyclin D1, CD56, CK18, p53, and PCNA showed that none of those markers is distinguishable between BCNS-associated and sporadic OKCs, in a 95% confidence interval. The risk of bias was high in 34 studies, moderate in 22, and low in 15.

conclusionsThe present systematic review and meta-analysis uncovered that, although several immunohistochemical markers might characterize the OKC phenotype, they cannot discriminate between the BCNS-associated and sporadic OKCs. CLINICAL RELEVANCE: This study highlighted the requirement for additional screening for markers by immunohistochemistry, preferentially coupled to alternative diagnostic applications such as genomics technologies.

Indexed as

Basal Cell Nevus SyndromeOdontogenic CystsOdontogenic TumorsHumansImmunohistochemistryNeoplasm Recurrence, LocalBasal cell nevus syndromeImmunohistochemistryMeta-analysisNevoid basal cell carcinoma syndromeOdontogenic keratocystSystematic review

Identifiers

PMID33730212
OpenAlexW3136752666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.