ArticleBrain : a journal of neurology2021
Activation of the basal ganglia and indirect pathway neurons during frontal lobe seizures.
Article in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Antiseizure Networks.Epilepsy currents · 2026Article
- The active role of non-synaptic electromagnetic induction in modulating absence epilepsy: a kinetic modeling study.Biological cybernetics · 2026Article
- Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy.Annals of clinical and translational neurology · 2026Article
- Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats.Epilepsia · 2026Article
- Increased volumes of the precuneus and the pallidum in idiopathic generalized epilepsy.Scientific reports · 2025Article
- Predictors and clinical implications of post-stroke cognitive impairment: a retrospective study.Scientific reports · 2025Article
- Thrombin mediates seizures following cortical injury-induced status epilepticus.Epilepsy research · 2025Article
- Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Seizure network characterization by functional connectivity mapping and manipulation.Neurophotonics · 2025Article
- Biomechanical Effects of Seizures on Cerebral Dynamics and Brain Stress.Brain sciences · 2024Article
- Article
- Unexplained Causes of Glioma-Associated Epilepsies: A Review of Theories and an Area for Research.Cancers · 2023Review
- Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference.Brain : a journal of neurology · 2023Article
- Characteristics of ictal thalamic EEG in pediatric-onset neocortical focal epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Characteristics of ictal thalamic EEG in pediatric-onset neocortical focal epilepsy.medRxiv : the preprint server for health sciences · 2023Article
- Subthalamic nucleus stimulation attenuates motor seizures via modulating the nigral orexin pathway.Frontiers in neuroscience · 2023Article
- Intracranial direct electrical mapping reveals the functional architecture of the human basal ganglia.Communications biology · 2022Article
- Distinct Roles of Rodent Thalamus and Corpus Callosum in Seizure Generalization.Annals of neurology · 2022Article
- Neuronal circuits sustaining neocortical-injury-induced status epilepticus.Neurobiology of disease · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
There are no detailed descriptions of neuronal circuit active during frontal lobe motor seizures. Using activity reporter mice, local field potential recordings, tissue clearing, viral tracing, and super-resolution microscopy, we found neuronal activation after focal motor to bilateral tonic-clonic seizures in the striatum, globus pallidus externus, subthalamic nucleus, substantia nigra pars reticulata and neurons of the indirect pathway. Seizures preferentially activated dopamine D2 receptor-expressing neurons over D1 in the striatum, which have different projections. Furthermore, the D2 receptor agonist infused into the striatum exerted an anticonvulsant effect. Seizures activate structures via short and long latency loops, and anatomical connections of the seizure focus determine the seizure circuit. These studies, for the first time, show activation of neurons in the striatum, globus pallidus, subthalamic nucleus, and substantia nigra during frontal lobe motor seizures on the cellular level, revealing a complex neuronal activation circuit subject to modulation by the basal ganglia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.