ArticlePLoS neglected tropical diseases2021
Bone sporotrichosis: 41 cases from a reference hospital in Rio de Janeiro, Brazil.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Susceptibility Profiles Among Sporothrix brasiliensis Genotypes in the Ongoing Zoonotic Sporotrichosis Epidemic in Brazil, Argentina and Paraguay.Mycopathologia · 2026Article
- Localized Cutaneous Versus Deep Sporotrichosis at Hospital das Clínicas, UFMG, Belo Horizonte, Brazil: A Cohort of 213 Culture-Confirmed Cases, 2011 to 2026.Journal of fungi (Basel, Switzerland) · 2026Article
- Osteoarticular Sporotrichosis in a Brazilian Endemic Setting: Associated Factors and Outcomes.Mycoses · 2026Article
- Unusual Sporotrichosis: A New Concept Proposal on the Unexpected Faces ofJournal of fungi (Basel, Switzerland) · 2026Review
- Variability of clinical presentation and diagnostic challenges in osteoarticular sporotrichosis: a case series.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- From neglected to notable: A growing public health challenge driven by hospitalization for sporotrichosis in Pernambuco, Northeast Brazil (2016-2024).PLoS neglected tropical diseases · 2025Article
- Extracutaneous sporotrichosis.Clinical microbiology reviews · 2025Review
- Sporotrichosis: an overview of the neglected disease reported worldwide in the last five years.Revista da Sociedade Brasileira de Medicina Tropical · 2025Review
- Systemic disseminated zoonotic sporotrichosis with multifocal bone involvement: A case report.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2025Article
- Sporotrichosis during pregnancy: A retrospective study of 58 cases in a reference center from 1998 to 2023.PLoS neglected tropical diseases · 2024Article
- Musculoskeletal involvement in neglected tropical diseases: a comprehensive review.Skeletal radiology · 2024Review
- Analysis of epidemiological and clinical aspects in cases of fungal osteomyelitis caused by non-Candida species.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Review
- A case of disseminated sporotrichosis.Southern African journal of infectious diseases · 2024Article
- The present and future research agenda of sporotrichosis on the silver anniversary of zoonotic sporotrichosis in Rio de Janeiro, Brazil.Memorias do Instituto Oswaldo Cruz · 2024Article
- Disseminated sporotrichosis with osteoarticular involvement in a patient with acquired immunodeficiency syndrome: a case report.Revista da Sociedade Brasileira de Medicina Tropical · 2024Article
- Case Report: Osteomyelitis Due to Sporothrix brasiliensis in Two Immunocompetent Patients Requiring Surgical Amputation.The American journal of tropical medicine and hygiene · 2023Article
- Osteoarticular Sporotrichosis of the Knee Caused byJournal of fungi (Basel, Switzerland) · 2023Article
- Sporotrichosis in the nasal mucosa: A single-center retrospective study of 37 cases from 1998 to 2020.PLoS neglected tropical diseases · 2023Article
- Beyond Domestic Cats: Environmental Detection ofJournal of fungi (Basel, Switzerland) · 2022Article
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12 authors.
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Abstract
backgroundBone sporotrichosis is rare. The metropolitan region of Rio de Janeiro is hyperendemic for zoonotic sporotrichosis and the bone presentations are increasing.
methodsWe studied a retrospective cohort of 41 cases of bone sporotrichosis, diagnosed from 1999-2016. The inclusion criteria was fungal culture isolation from any clinical specimen associated to bone involvement (radiography and/or computed tomography) compatible with fungal osteomyelitis or histopathological findings of bone material compatible with sporotrichosis. Molecular identification was performed when possible.
resultsMale patients represented 58.5% of the cases, with a cohort median age of 43 years. Immunosuppressive conditions were present in 68.3% of the patients, mostly HIV coinfection (51.2%). Multifocal bone involvement (more than one anatomical segment) was diagnosed in 61% of the patients, while 39% presented unifocal involvement. The bones of the hands were the most affected (58.5%), followed by the feet (41.5%) and tibia (26.8%). Multifocal group was characterized by a higher proportion of males (p = 0.0045) with immunosuppressive conditions (p = 0.0014). Amphotericin B followed by oral itraconazole was the main treatment, with a median time of 16.7 months (1.5 to 99.2 months), and cure of 53.7% of the patients (84.6% of immunocompetent and 39.3% of immunocompromised patients). Sequelae occurred in 12.2% of the patients-amputations (7.3%) and ankylosis (4.9%), while 22% died in the course of the disease. Sporothrix brasiliensis was the causative agent in all the 9 (22%) performed cases.
conclusionsBone sporotrichosis is a chronic, challenging condition with prolonged treatment, often with poor results and sequelae.
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