Evidence map›Paper›PMID 33729999›Full record

ArticleJCI insight2021

Gut-derived acetate promotes B10 cells with antiinflammatory effects.

C I Daïen, J Tan, R Audo, J Mielle, L E Quek, J R Krycer, A Angelatos, M Duraes, G Pinget, D Ni and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Influence of Alcohol on the Intestinal Immune System.Alcohol research : current reviews · 2025
    Pooled it
  2. Review
  3. Article
  4. Lipid metabolism in homeostasis and disease.Signal transduction and targeted therapy · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. NRF2 is a spatiotemporal metabolic hub essential for the polyfunctionality of Th2 cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 1 country.

C I DaïenCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
J TanCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
R AudoCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
J MielleCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
L E QuekCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
J R KrycerCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
A AngelatosCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
M DuraesDepartment of Gynecology, Montpellier Hospital, University of Montpellier, Montpellier, France.
G PingetCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
D NiCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
R RobertDepartment of Physiology and.
M J AlamDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
M C B AmianCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
F SierroFaculty of Medicine and Health, The University of Sydney School of Medicine, New South Wales, Sydney, Australia.
A ParmarHuman Health, Nuclear Science & Technology and Landmark Infrastructure (NSTLI) Australian Nuclear Science and Technology Organisation, New South Wales, Sydney, Australia.
G PerkinsBiosciences platform, NSTLI Australian Nuclear Science and Technology Organisation, New South Wales, Sydney, Australia.
S HoqueCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
A K GosbyCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
S J SimpsonCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
R V RibeiroCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
C R MackayDepartment of Physiology and.
L MaciaCharles Perkins Centre, The University of Sydney, New South Wales, Sydney, Australia.
University of Sydney · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune diseases are characterized by a breakdown of immune tolerance partly due to environmental factors. The short-chain fatty acid acetate, derived mostly from gut microbial fermentation of dietary fiber, promotes antiinflammatory Tregs and protects mice from type 1 diabetes, colitis, and allergies. Here, we show that the effects of acetate extend to another important immune subset involved in tolerance, the IL-10-producing regulatory B cells (B10 cells). Acetate directly promoted B10 cell differentiation from mouse B1a cells both in vivo and in vitro. These effects were linked to metabolic changes through the increased production of acetyl-coenzyme A, which fueled the TCA cycle and promoted posttranslational lysine acetylation. Acetate also promoted B10 cells from human blood cells through similar mechanisms. Finally, we identified that dietary fiber supplementation in healthy individuals was associated with increased blood-derived B10 cells. Direct delivery of acetate or indirect delivery via diets or bacteria that produce acetate might be a promising approach to restore B10 cells in noncommunicable diseases.

Indexed as

AcetatesAcetylationAcetyl Coenzyme AAnimalsArthritis, ExperimentalB-Lymphocytes, RegulatoryCell DifferentiationDietary FiberFatty Acids, VolatileFemaleHumansInterleukin-10MaleMiceMice, Inbred C57BLMice, Mutant StrainsAcetatesAcetyl Coenzyme ADietary FiberFatty Acids, VolatileFfar2 protein, mouseIL10 protein, mouseInterleukin-10Receptors, G-Protein-CoupledBeta cellsImmunologyMetabolism

Identifiers

PMID33729999
PMCPMC8119207
OpenAlexW3138809126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.