Evidence map›Paper›PMID 33729949›Full record

ArticleIEEE transactions on biomedical circuits and systems2021

Design and Testing of Stimulation and Myoelectric Recording Modules in an Implanted Distributed Neuroprosthetic System.

Nathaniel Makowski, Alexandru Campean, Joris Lambrecht, James Buckett, James Coburn, Ronald Hart, Michael Miller, Fred Montague, Timothy Crish, Michael Fu and 3 more

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in IEEE transactions on biomedical circuits and systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02329652 narecruitingnot on this map

Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury

TypeinterventionalSponsorAnne BrydenRan2014 to 2031Enrolled30ConditionsSpinal Cord Injuries, Spinal Cord Injury at C5-C7 Level, Spinal Cord Injury Cervical, Spinal Cord Injury at C5-C7 Level With Complete LesionArmsNetworked Neuroprosthetic System for Grasp and Trunk
NCT05863754 narecruitingnot on this mapstarted 2022, after this paper: background citation

Grasp-Release Assessment of a Networked Neuroprosthesis Device

TypeinterventionalSponsorMetroHealth Medical CenterRan2022 to 2028Enrolled13ConditionsSpinal Cord Injury at C5-C7 Level, Spinal Cord Injuries, Spinal Cord Injury CervicalArmsNetworked Neuroprosthesis Device
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Lower limb functional electrical stimulation improves stair stepping in an individual with stroke: a case report.International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Trunk Posture from Randomly Oriented Accelerometers.Sensors (Basel, Switzerland) · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Nathaniel Makowski
Alexandru Campean
Joris Lambrecht
James Buckett
James Coburn
Ronald Hart
Michael Miller
Fred Montague
Timothy Crish
Michael Fu
Kevin Kilgore
P Hunter Peckham
Brian Smith
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · USMetroHealth Medical Center · USCleveland FES Center · USSynapse Biomedical (United States) · US

Funding

Development of Networked Implantable NeuroprosthesesR01EB001740 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI PECKHAM, PAUL HUNTER · 2005 to 2015
$9.3M
Restoration of Grasp and Reach in Cervical Spinal Cord InjuryUH3NS103863 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI BRYDEN, ANNE, KILGORE, KEVIN L. · 2019 to 2024
$8.1M
Multi-functional Neuroprosthetic Systems for Restoration of Motor FunctionU01NS069517 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI PECKHAM, PAUL HUNTER · 2010 to 2016
$7.2M
Restoration of Grasp and Reach in Cervical Spinal Cord InjuryUH2NS103863 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI PECKHAM, PAUL HUNTER · 2018 to 2018
$1.5M
NIBIB NIH HHS R01 EB001740NINDS NIH HHS U01 NS069517NINDS NIH HHS UH2 NS103863NINDS NIH HHS UH3 NS103863
6 · The paper itself

Abstract

Implantable motor neuroprostheses can restore functionality to individuals with neurological disabilities by electrically activating paralyzed muscles in coordinated patterns. The typical design of neuroprosthetic systems relies on a single multi-use device, but this limits the number of stimulus and sensor channels that can be practically implemented. To address this limitation, a modular neuroprosthesis, the "Networked Neuroprosthesis" (NNP), was developed. The NNP system is the first fully implanted modular neuroprosthesis that includes implantation of all power, signal processing, biopotential signal recording, and stimulating components. This paper describes the design of stimulation and recording modules, bench testing to verify stimulus outputs and appropriate filtering and recording, and validation that the components function properly while implemented in persons with spinal cord injury. The results of system testing demonstrated that the NNP was functional and capable of generating stimulus pulses and recording myoelectric, temperature, and accelerometer signals. Based on the successful design, manufacturing, and testing of the NNP System, multiple clinical applications are anticipated.

Indexed as

Electric Stimulation TherapySpinal Cord InjuriesComputer Communication NetworksHumansProstheses and ImplantsSignal Processing, Computer-Assisted

Identifiers

PMID33729949
PMCPMC8344369
OpenAlexW3137795297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.