Evidence map›Paper›PMID 33729746›Full record

ArticleBiochemistry2021

A Dynamic Substrate is Required for MhuD-Catalyzed Degradation of Heme to Mycobilin.

Biswash Thakuri, Bruce D O'Rourke, Amanda B Graves, Matthew D Liptak

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Heme and immunity: The heme oxygenase dichotomy.Journal of inorganic biochemistry · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Biswash ThakuriDepartment of Chemistry, University of Vermont, Burlington, Vermont 05405, United States.
Bruce D O'RourkeDepartment of Chemistry, University of Vermont, Burlington, Vermont 05405, United States.
Amanda B GravesDepartment of Chemistry, University of Vermont, Burlington, Vermont 05405, United States.
Matthew D LiptakDepartment of Chemistry, University of Vermont, Burlington, Vermont 05405, United States.ORCID 0000-0002-4951-6636
University of Vermont · US

Funding

Heme Oxygenases: chemically complex enzymes found in diverse biological pathwaysR35GM139516 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Matthew D Liptak · 2021 to 2026
$1.7M
Second-Sphere Influences on Oxygen Activation by Non-Canonical Heme OxygenasesR01GM114277 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LIPTAK, MATTHEW D · 2016 to 2020
$1.5M
NIGMS NIH HHS R01 GM114277NIGMS NIH HHS R35 GM139516
6 · The paper itself

Abstract

The noncanonical heme oxygenase MhuD from

Indexed as

HemeHeme Oxygenase (Decyclizing)Mycobacterium tuberculosisBacterial ProteinsKineticsSubstrate SpecificityBacterial ProteinsHemeHeme Oxygenase (Decyclizing)

Identifiers

PMID33729746
PMCPMC8628293
OpenAlexW3106801717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.